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Anti-TRIM63 Antibody (5C208)
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产品编号 TMAC-02688
别名 Tripartite motif-containing protein 63, TRIM 63, Striated muscle RING zinc finger protein, SMRZ, RNF 28, RING-type E3 ubiquitin transferase TRIM63, Muscle-specific RING finger protein 1 (MuRF-1, MuRF1), MuRF1, MURF1, Iris RING finger protein, IRF, E3 ubiquitin-protein ligase TRIM63
Anti-TRIM63 Antibody (5C208) 是一种 Mouse 抗体，靶向 TRIM63。Anti-TRIM63 Antibody (5C208) 可用于 ICC,IHC,FCM。
Anti-TRIM63 Antibody (5C208)
Anti-TRIM63 Antibody (5C208)
还可以产品编号 TMAC-02688 别名 Tripartite motif-containing protein 63, TRIM 63, Striated muscle RING zinc finger protein, SMRZ, RNF 28, RING-type E3 ubiquitin transferase TRIM63, Muscle-specific RING finger protein 1 (MuRF-1, MuRF1), MuRF1, MURF1, Iris RING finger protein, IRF, E3 ubiquitin-protein ligase TRIM63
Anti-TRIM63 Antibody (5C208) 是一种 Mouse 抗体，靶向 TRIM63。Anti-TRIM63 Antibody (5C208) 可用于 ICC,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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| 产品描述 | Anti-TRIM63 Antibody (5C208) is a Mouse antibody targeting TRIM63. Anti-TRIM63 Antibody (5C208) can be used in ICC,IHC,FCM. |
| 别名 | Tripartite motif-containing protein 63, TRIM 63, Striated muscle RING zinc finger protein, SMRZ, RNF 28, RING-type E3 ubiquitin transferase TRIM63, Muscle-specific RING finger protein 1 (MuRF-1, MuRF1), MuRF1, MURF1, Iris RING finger protein, IRF, E3 ubiquitin-protein ligase TRIM63 |
| 克隆号 | 5C208 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using anti-MuRF1 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded huamn muscle tissues using anti-MuRF1 antibody. Counter stained with hematoxylin. 3. ICC staining MuRF1(green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. Flow cytometric analysis of Hela cells with MuRF1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red). |
| 应用 | |
| 推荐剂量 | IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Muscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 40 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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