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Anti-Ube2N Antibody (8H957) 是一种 Rabbit 抗体,靶向 Ube2N。Anti-Ube2N Antibody (8H957) 可用于 WB。
Anti-Ube2N Antibody (8H957) 是一种 Rabbit 抗体,靶向 Ube2N。Anti-Ube2N Antibody (8H957) 可用于 WB。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,485 | 5日内发货 | |
100 μL | ¥ 2,495 | 5日内发货 |
产品描述 | Anti-Ube2N Antibody (8H957) is a Rabbit antibody targeting Ube2N. Anti-Ube2N Antibody (8H957) can be used in WB. |
别名 | Yeast UBC13 homolog, Ubiquitin-protein ligase N, Ubiquitin-conjugating enzyme E2 N, Ubiquitin protein ligase N, Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast), Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13), Ubiquitin conjugating enzyme E2N, Ubiquitin conjugating enzyme E2 N, Ubiquitin carrier protein N, UBE2N_HUMAN, Ube2n, Ube 2N, UbcH-ben, UBCHBEN, UbcH13, UbCH ben, Ubc13, UBC 13, MGC8489, MGC131857, Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds, HEL-S-71, Epididymis secretory protein Li 71, EC 6.3.2.19, BLU, Bendless-like ubiquitin-conjugating enzyme, Bendless like ubiquitin conjugating enzyme |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. Western blot analysis of Ube2N on different lysates using anti-Ube2N antibody at 1/1,000 dilution. Positive control: Lane 1: Daudi, Lane 2: SH-SY-5Y, Lane 3: Mouse spleen, Lane 4: Rat spleen. |
应用 | |
推荐剂量 | WB: 1:500-2000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Ube2N, a member of the E2 Ubiquitin-conjugating enzyme family, completes the second step of ubiquitination reactions, essentially targeting proteins for proteasomic degradation. When proteins are modified with ubiquitin in an important cellular mechanism targeting abnormal or short lived proteins, ubiquitin, a short protein of 76 amino acids, attaches to a lysine residue resting on the target protein. Multiple cycles of ubiquitination create a polyubiquitin chain that the proteasome recognizes and subsequently triggers the ATP-dependent unfolding of the target protein. This allows protoeolytic degradation of the target protein. These degradation products are highly expressed in heart and skeletal muscles. Ube2N moderates the transcriptional activation of target genes, affects the progress of cell differentiation and aging, and also influences the DNA repair pathway, further adding to the survival of cells after DNA damage. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein: human Ube2N aa 1-150 |
抗原种属 | human |
Uniprot ID |
分子量 | Theoretical: 17 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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