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ACKR1 Protein, Human, Recombinant (His)

产品编号 TMPH-00990

别名: Glycoprotein D, Duffy antigen/chemokine receptor, Atypical chemokine receptor 1, Plasmodium vivax receptor, GpFy, CD234, Fy glycoprotein

ACKR1 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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ACKR1 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
20 μg	￥ 12,400		20日内发货
100 μg	￥ 19,800		20日内发货

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生物活性

技术参数

产品性质

生物活性	Measured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/mL can bind human CCL2, the EC50 of human CCL2 protein is 48.64-60.24 μg/mL.
产品描述	ACKR1 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system.

种属	Human
表达系统	in vitro E. coli expression system
标签	N-terminal 10xHis-tagged
蛋白编号	Q16570
别名	Glycoprotein D, Duffy antigen/chemokine receptor, Atypical chemokine receptor 1, Plasmodium vivax receptor, GpFy, CD234, Fy glycoprotein
氨基酸序列	MGNCLHRAELSPSTENSSQLDFEDVWNSSYGVNDSFPDGDYGANLEAAAPCHSCNLLDDSALPFFILTSVLGILASSTVLFMLFRPLFRWQLCPGWPVLAQLAVGSALFSIVVPVLAPGLGSTRSSALCSLGYCVWYGSAFAQALLLGCHASLGHRLGAGQVPGLTLGLTVGIWGVAALLTLPVTLASGASGGLCTLIYSTELKALQATHTVACLAIFVLLPLGLFGAKGLKKALGMGPGPWMNILWAWFIFWWPHGVVLGLDFLVRSKLLLLSTCLAQQALDLLLNLAEALAILHCVATPLLLALFCHQATRTLLPSLPLPEGWSSHLDTLGSKS
蛋白构建	1-336 aa
蛋白纯度	> 85% as determined by SDS-PAGE.
分子量	41.1 kDa (predicted)

缓冲液	Tris-based buffer，50% glycerol
复溶方法	A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

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Keywords

ACKR1 Protein, Human, Recombinant (His) Glycoprotein D Duffy antigen/chemokine receptor Atypical chemokine receptor 1 Plasmodium vivax receptor GpFy CD234 Fy glycoprotein recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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