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Anti-AGER Monoclonal Antibody-Biotin

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Anti-AGER Monoclonal Antibody-Biotin
产品编号 TMAZ-0128B
别名 Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor

Anti-AGER Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody-Biotin can be used in ELISA, FCM.

Anti-AGER Monoclonal Antibody-Biotin

Anti-AGER Monoclonal Antibody-Biotin

Rating icon 还可以
Anti-AGER Monoclonal Antibody-Biotin
产品编号 TMAZ-0128B 别名 Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor

Anti-AGER Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody-Biotin can be used in ELISA, FCM.

规格价格库存数量
25 μg
¥ 1,874
7日内发货
50 μg
¥ 2,248
7日内发货
100 μg
¥ 3,147
7日内发货
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实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-AGER Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody-Biotin can be used in ELISA, FCM.
别名Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of AGER overexpressed 297F cells with TMAZ-0128B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
推荐剂量
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AGER protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in PBS.
纯度> 95% as determined by SDS-PAGE.
研究背景Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed: 27572515, PubMed: 28515150, PubMed: 34743181). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed: 21565706). These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed: 21829704). Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed: 19386136). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed: 19906677). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed: 27572515). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed: 34743181). Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed: 24081950, PubMed: 28515150)
偶联与修饰
偶联
Biotin
其他可选修饰符
Unconjugated
可提供抗体种类
2
抗原信息
免疫原
AGER
抗原种属
Human
基因ID
Uniprot ID
研究领域
Cancer Research
化学信息
分子量150 kDa
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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