HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is NP_001162100.2.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 μg | ¥ 3,170 | 5日内发货 | ||
100 μg | ¥ 7,550 | 5日内发货 |
生物活性 | Testing in progress |
产品描述 | HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is NP_001162100.2. |
种属 | Cynomolgus,Rhesus |
表达系统 | HEK293 Cells |
标签 | C-His |
蛋白编号 | NP_001162100.2 |
别名 | MET proto-oncogene, receptor tyrosine kinase |
蛋白构建 | The cynomolgus/rhesus MET (A0A2K5UM36-1 / NP_001162100.2) (Met1-Thr932) was expressed with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus MET sequences are identical. The purified protein was biotinylated in vitro. |
蛋白纯度 | ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
分子量 | 103.1 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
bottom
您可能有的问题的答案可以在重组蛋白操作手册中找到
HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated MET proto-oncogene, receptor tyrosine kinase recombinant recombinant-proteins proteins protein