Anti-LEU5 Polyclonal Antibody is a Rabbit antibody targeting LEU5. Anti-LEU5 Polyclonal Antibody can be used in WB.

Tripartite motif protein 13, TRIM13, TRI13, RNF77, RING finger protein 77, Ret finger protein 2, Putative tumor suppressor RFP2, Leukemia associated protein 5, LEU5, HGNC:9976, DLEU5, CAR, B cell chronic lymphocytic leukemia tumor suppressor Leu5

IgG

Human,Mouse,Rat (predicted:Dog,Pig,Horse,Rabbit,Sheep)

1. Sample:
Liver (Mouse) Lysate at 40 μg
Primary: Anti-LEU5 (TMAB-01062) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kDa
Observed band size: 48 kDa
2. Sample:
Lane 1: Mouse Testis Lysates
Lane 2: Rat Testis Lysates
Lane 3: Rat LympHLysates
Lane 4: Human HL-60 cell Lysates
Lane 5: Human SH-SY5Y cell Lysates
Lane 6: Human HeLa cell Lysates
Primary: Anti-LEU5 (TMAB-01062) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa

WB: 1:500-2000

Polyclonal

KLH conjugated synthetic peptide: human LEU5/RFP2

Human

TRIM13

E3 ubiquitin-protein ligase TRIM13

Cell Cycle Inhibitors,Ubiquitin ligases,Ubiquitylation,Developmental Families,NFkB Pathway

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.