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顶部生物活性储存和溶解信息计算器

Anti-SMAD4 Antibody (7P892)

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产品编号 TMAH-01109

别名 SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4

Anti-SMAD4 Antibody (7P892) 是一种抗体，靶向 SMAD4。Anti-SMAD4 Antibody (7P892) 可用于 ELISA,WB。

Anti-SMAD4 Antibody (7P892)

Anti-SMAD4 Antibody (7P892)

一键复制产品信息
Rating icon 还可以
产品编号 TMAH-01109 别名 SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4

Anti-SMAD4 Antibody (7P892) 是一种抗体，靶向 SMAD4。Anti-SMAD4 Antibody (7P892) 可用于 ELISA,WB。

规格价格库存数量
50 μL
¥ 1,310
5日内发货
100 μL
¥ 2,190
5日内发货
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产品介绍

生物活性
产品描述
Anti-SMAD4 Antibody (7P892) is an antibody targeting SMAD4. Anti-SMAD4 Antibody (7P892) can be used in ELISA,WB.
别名SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4
Ig Type
Rabbit IgG
克隆号
7P892
交叉反应
Human
验证活性
Western Blot
-Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate, MCF-7 whole cell lysate
-All lanes: SMAD4 antibody at 1:500
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 61 kDa
-Observed band size: 55-72 kDa
应用ELISAWB
推荐剂量
WB:1:500-1:2000.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Nucleus.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human SMAD4
抗原种属
Human
基因名称
SMAD4
基因ID
4089
Uniprot ID
Q13485
研究领域
Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Metabolism, Signal transduction, Stem cells
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

SMAD-4MADH-4MADH 4DPC-4DPC 4

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