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Anti-PNPLA2 Polyclonal Antibody

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Anti-PNPLA2 Polyclonal Antibody
产品编号 TMAB-01554
别名 TTS2.2, Transport-secretion protein 2 (TTS2), PNPLA2, Pigment epithelium-derived factor receptor (PEDF-R), Patatin-like phospholipase domain-containing protein 2, Desnutrin, Calcium-independent phospholipase A2-zeta (iPLA2-zeta), ATGL, Adipose triglyceride lipase

Anti-PNPLA2 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 PNPLA2。Anti-PNPLA2 Polyclonal Antibody 可用于 WB,FCM。

Anti-PNPLA2 Polyclonal Antibody

Anti-PNPLA2 Polyclonal Antibody

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Anti-PNPLA2 Polyclonal Antibody
产品编号 TMAB-01554 别名 TTS2.2, Transport-secretion protein 2 (TTS2), PNPLA2, Pigment epithelium-derived factor receptor (PEDF-R), Patatin-like phospholipase domain-containing protein 2, Desnutrin, Calcium-independent phospholipase A2-zeta (iPLA2-zeta), ATGL, Adipose triglyceride lipase

Anti-PNPLA2 Polyclonal Antibody 是一种 Rabbit 抗体,靶向 PNPLA2。Anti-PNPLA2 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-PNPLA2 Polyclonal Antibody is a Rabbit antibody targeting PNPLA2. Anti-PNPLA2 Polyclonal Antibody can be used in WB,FCM.
别名TTS2.2, Transport-secretion protein 2 (TTS2), PNPLA2, Pigment epithelium-derived factor receptor (PEDF-R), Patatin-like phospholipase domain-containing protein 2, Desnutrin, Calcium-independent phospholipase A2-zeta (iPLA2-zeta), ATGL, Adipose triglyceride lipase
Ig Type
IgG
交叉反应
Human,Mouse (predicted:Rat)
验证活性
1. Sample:
Lane 1: Mouse Brown fat tissue lysates
Lane 2: Mouse Heart tissue lysates
Primary: Anti-Adipose Triglyceride Lipase (TMAB-01554) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kDa
Observed band size: 52 kDa
2. Blank control: A431. Primary Antibody (green line): Rabbit Anti-Adipose Triglyceride Lipase antibody (TMAB-01554)
Dilution: 3 μg/10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG.
Secondary Antibody: Goat anti-rabbit IgG-AF647
Dilution: 3 μg/test.
Protocol
The cells were incubated in 5% BSA to block non-specific protein-protein interactions for 30 min at at room temperature. Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature.
应用
推荐剂量
WB: 1:500-2000; FCM: 3ug/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Lipid droplet. Cell membrane.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景Adipose triglyceride lipase (ATGL) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. ATGL catalyzes the initial step in triglyceride hydrolysis in mammalian adipose tissue. ATGL contains a patatin domain common to plant acyl hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ATGL
抗原种属
Human
基因ID
Uniprot ID
研究领域
Lipases,Lipases,Metabolic disorders,Obesity,Lipid metabolism
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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