Placental Lactogen/CSH1 Protein, Human, Recombinant (His), Biotinylated

Placental Lactogen/CSH1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.7 kDa and the accession number is A8K6C2.

规格	价格/CNY		货期	数量
20 μg	￥ 2,440	5日内发货
100 μg	￥ 5,810	5日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 2,440

5日内发货

100 μg

￥ 5,810

5日内发货

生物活性	Testing in progress
产品描述	Placental Lactogen/CSH1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.7 kDa and the accession number is A8K6C2.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	A8K6C2
别名	hCS-A, CS-1, CSA, hCS-1, PL, CSMT, chorionic somatomammotropin hormone 1 (placental lactogen)
蛋白构建	The Human CSH1 (NP_001308.1) (Met1-Phe217) was expressed, fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 87 % as determined by SDS-PAGE
分子量	23.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Chorionic somatomammotropin hormone, also known as Choriomammotropin, Lactogen, Placental lactogen and CSH1, is a secreted protein which belongs to thesomatotropin / prolactin family. CSH1 is produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The CSH1 gene is member of the GH gene cluster on 17q, which consists of two growth hormone genes and three CSH genes. Genomic alterations in the GH cluster are well known, causing different phenotypes depending on the size of the deletion and the genes involved. The increased prevalence of hemizygosity of CSH1 in population in comparison to controls indicates a role for CSH1 haploinsufficiency in the etiology of growth retardation. Investigation of CSH1 deletions in further SRS and growth retarded patients will enable us to establish under which circumstances haploinsufficiency of CSH1 is likely to result in clinical changes.