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Mer Protein, Human, Recombinant

产品编号 TMPY-04330

别名: MER proto-oncogene, tyrosine kinase, RP38, MER, c-mer, Tyro12, c-Eyk

Mer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 54 kDa and the accession number is Q12866.

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Mer Protein, Human, Recombinant

规格	价格/CNY		货期	数量
100 μg	￥ 4,470		现货
200 μg	￥ 7,630		5日内发货
500 μg	￥ 15,450		5日内发货

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生物活性	Testing in progress
产品描述	Mer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 54 kDa and the accession number is Q12866.

种属	Human
表达系统	HEK293 Cells
标签	Tag Free
蛋白编号	Q12866
别名	MER proto-oncogene, tyrosine kinase, RP38, MER, c-mer, Tyro12, c-Eyk
蛋白构建	The mature form of Human Mer (NP_006334.2) extracellular domain (Met 1-Ala 499) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	54 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM NaCl, 50 mM Tris, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in the membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in the testis, ovary, prostate, lung, and kidney, with lower expression in the spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. MERTK plays also an important role in the inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.

参考文献

1. Thompson DA,et al. (2002) Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. Am J Hum Genet. 70 (1): 224-9. 2. Tada A,et al. (2006) Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. Mol Vis. 12: 441-4. 3. McHenry CL,et al. (2004) MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. Invest Ophthalmol. Vis Sci. 45 (5): 1456-63.

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Keywords

Mer Protein, Human, Recombinant MER proto-oncogene, tyrosine kinase RP38 MER c-mer RP-38 RP 38 Tyro12 c-Eyk recombinant recombinant-proteins proteins protein

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