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Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc)

产品编号 TMPY-00810

别名: Human cytωlovirus (HCMV) Glycoprotein B/gB

Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 118 kDa and the accession number is P13201.

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Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 5,750		5日内发货

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参考文献

生物活性	Measured by its ability to bind biotinylated Human CD209-Fc in functional ELISA.
产品描述	Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 118 kDa and the accession number is P13201.

种属	CMV
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P13201
别名	Human cytωlovirus (HCMV) Glycoprotein B/gB
蛋白构建	The extracellular domain (Met 1-Lys 700) linked with the cytoplasmic domain (Arg 777-Val 907) of Human CMV gB (AAA45920.1, with furin cleavage site mutated from 'RTKR' to 'TTQT') precursor was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 80 % as determined by SDS-PAGE
分子量	118 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Gly, 10 mM NaCl, 50 mM Tris, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B, also referred as CMV gB or gB, which belongs to the herpesviridae glycoprotein B family. It is a 97-amino acid glycoprotein encoded by the ORF of UL55. Cytomegalovirus Glycoprotein B protein is the most abundant component of the envelope, a target of neutralizing antibodies with at least two defined neutralizing epitopes and an essential replication component. Cytomegalovirus Glycoprotein B protein plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. In addition, Cytomegalovirus Glycoprotein B protein is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.

参考文献

1. Lopper M,et al.(2002). Disulfide bond configuration of human cytomegalovirus glycoprotein B. J Virol. 76(12): 6073-82. 2. Isaacson MK,et al.(2009) Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress. J Virol. 83(8): 3891-903.

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Keywords

Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc) Human cytωlovirus (HCMV) Glycoprotein B/gB recombinant recombinant-proteins proteins protein

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