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Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893)
还可以产品编号 TMAY-00460F
Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893) 是一种 FITC-conjugated Mouse 抗体，靶向 E-Cadherin/Cadherin-1。Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893) 可用于 FCM。
Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893)
Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893)
还可以产品编号 TMAY-00460F
Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893) 是一种 FITC-conjugated Mouse 抗体，靶向 E-Cadherin/Cadherin-1。Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893) is a FITC-conjugated Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody-FITC (7W893) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 7W893 |
| 交叉反应 | Human |
| 验证活性 | 1. Profile of anti-E-cad (CD324) reactivity on MCF-7 cells analyzed by flow cytometry. 2. Immunofluorescence staining of Human E-CAD in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Mouse anti-Human MCF7 monoclonal antibody (FITC-conjugated, 10 µg/ml) at 37°C 1 hour, and counterstained with DAPI (blue). Positive staining was localized to plasma membrane. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cadherin-1 / CDH1 / CD324 / E-cadherin (rh Cadherin-1 / CDH1 / CD324 / E-cadherin; NP_004351.1Met 1-Ile 707) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/APC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CDH1 protein |
| 抗原种属 | Human |
| 研究领域 | Hemangioblast Markers, Tumor Suppressors |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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