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TargetMol | Compound Library

抗癌临床化合物库现货

Anti-Cancer Clinical Compound Library
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货号 L2120

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号(例如治疗药物)诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力，表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

抗癌活性的药物是临床研究的热点之一，根据文献报道和有关公开资料，我们收集了2760 个具有抗癌活性或潜在抗癌活性的处于临床试验阶段的化合物，组成抗癌临床化合物库，可用于癌症相关研究及高通量高内涵筛选。

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货号 L2120

抗癌临床化合物库

规格

  • 1 mg
  • 10 μL x 10 mM (in DMSO)
  • 20 μL x 10 mM (in DMSO)
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
询价 & 定制

产品描述 产品描述

  • 2760个具有抗癌活性小分子的独特集合，可用于高通量高内涵筛选；
  • 生物活性已经临床前实验证实，所有化合物均已进入临床实验阶段的抗癌化合物；
  • 包括肺癌、乳腺癌、白血病、淋巴瘤等15种癌症，是癌症相关研究的有效筛选工具；
  • 作用靶点涉及PI3K,HDAC, mTOR, CDK, JAK 等癌症相关靶点；
  • 结构多样，药效显著，可渗透细胞；
  • 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

包装和储存 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
  • 干粉蓝冰运输，DMSO溶液干冰运输；
  • 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
  • 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求，采用其他溶剂或浓度包装，具体以实际产品信息为准。

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Apoptosis
Autophagy
Endogenous Metabolite
5-HT Receptor
Antibacterial
Adrenergic Receptor
DNA/RNA Synthesis
Dopamine Receptor
Antibiotic
VEGFR
COX
Potassium Channel
Histamine Receptor
Calcium Channel
EGFR
Sodium Channel
Parasite
PI3K
ROS
CDK
Cytochromes P450
Reactive Oxygen Species
NF-κB
FLT
JAK
PDGFR
HIV Protease
Glucocorticoid Receptor
FGFR
Topoisomerase
c-Kit
mTOR
HDAC
Akt
c-Met/HGFR
Microtubule Associated
PPAR
Ferroptosis
Virus Protease
AChR
SARS-CoV
Prostaglandin Receptor
Src
GABA Receptor
p38 MAPK
Dehydrogenase
Nucleoside Antimetabolite/Analog
Estrogen Receptor/ERR
ERK
Mitophagy
Antifungal
Interleukin
iGluR
Adenosine Receptor
Estrogen/progestogen Receptor
Bcr-Abl
Tyrosine Kinases
Influenza Virus
Caspase
Androgen Receptor
Ras
GPCR
TNF
Epigenetic Reader Domain
Raf
PARP
BTK
HSP
P-gp
HSV
Aurora Kinase
Bcl-2 Family
ALK
MDM-2/p53
Serotonin Transporter
PDE
TRP/TRPV Channel
MEK
HER
Trk receptor
HIF/HIF Prolyl-Hydroxylase
HBV
RAAS
c-RET
Histone Methyltransferase
Opioid Receptor
PKC
STAT
Mitochondrial Metabolism
Phosphatase
Norepinephrine
TLR
c-Fms
ATPase
Wnt/beta-catenin
ROS Kinase
Endothelin Receptor
AMPK
HCV Protease
NMDAR
JNK
MMP
E1/E2/E3 Enzyme
GSK-3
TAM Receptor
Drug Metabolite
FAK
DNA Alkylator/Crosslinker
Beta Amyloid
Chk
Progesterone Receptor
LPL Receptor
Proton pump
Retinoid Receptor
Molecular Glues
Gamma-secretase
S1P Receptor
Kras
Reverse Transcriptase
HIF
TGF-beta/Smad
Guanylate cyclase
CXCR
NO Synthase
SGLT
GluR
IGF-1R
CFTR
DNA-PK
Antifolate
Nrf2
p53
IL Receptor
Carbonic Anhydrase
PKA
DNA Alkylation
ATM/ATR
P2X Receptor
ROCK
S6 Kinase
Syk
Antioxidant
GNRH Receptor
Vasopressin Receptor
Hedgehog/Smoothened
ADC Cytotoxin
PLK
IAP
Mdm2
MAO
Isocitrate Dehydrogenase (IDH)
Lipoxygenase
DHFR
Integrin
CSF-1R
Ligands for E3 Ligase
Indoleamine 2,3-Dioxygenase (IDO)
HMG-CoA Reductase
Kinesin
Transferase
IDO
Anti-infection
Monoamine Oxidase
P2Y Receptor
Angiotensin-converting Enzyme (ACE)
MAPK
PAK
IRAK
IκB/IKK
MRP
Antifection
OX Receptor
Glutathione Peroxidase
Leukotriene Receptor
Cannabinoid Receptor
DNA Methyltransferase
Serine Protease
Histone Demethylase
Sirtuin
Casein Kinase
Smo
Phospholipase
RIP kinase
Antiviral
DNA
Hydroxylase
Sigma receptor
Ephrin Receptor
PD-1/PD-L1
Reductase
Tie-2
Neurokinin receptor
FXR
Bradykinin Receptor
Pim
Glucagon Receptor
DPP-4
PROTACs
CCR
IKZF
CRFR
GHSR
NOD
Proteasome
PYK2
Wee1
Serine/threonin kinase
Xanthine Oxidase
STING
Tyrosinase
IFNAR
Telomerase
Thrombin
NOD-like Receptor (NLR)
GPCR19
RSV
PERK
Cholinesterase (ChE)
Photosensitizer
NAMPT
GST
Aromatase
Oxytocin Receptor
Cholecystokinin Receptor
Glucosidase
CRM1
Glutaminase
Fatty Acid Synthase
Somatostatin
PGE Synthase
Chloride channel
Melatonin Receptor
Aryl Hydrocarbon Receptor
CGRP Receptor
YAP
NADPH
Na-K-Cl cotransporter
Neuropeptide Y Receptor
CaMK
AhR
DUB
ABC Transporter
Monoamine Transporter
glycosidase
c-Myc
CaSR
Rho
Melanocortin Receptor
Gap Junction Protein
Beta-Secretase
Decarboxylase
Adenosine Deaminase
BCRP
Survivin
Aminopeptidase
Cuproptosis
Discoidin Domain Receptor (DDR)
Protease-activated Receptor
IRE1
KSP
OXPHOS
Free radical scavengers
FKBP
MLK
Annexin A
MT Receptor
transporter
ROR
OAT
LTR
ATP Citrate Lyase
ribosome
Arginase
DYRK
HCN Channel
Histone Acetyltransferase
PAI-1
TOPK
Acyltransferase
UGT
Thrombopoietin Receptor
p97
NOS
Monocarboxylate transporter
Cysteine Protease
LDL
DNA gyrase
Huntingtin
Necroptosis
RANKL/RANK
GRK
LPA Receptor
PDK
SGK
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
Galectin
Hexokinase
PANoptosis
PI4K
Complement System
NEDD8
VDA
PROTAC Linker
Porcupine
CD73
PGC-1α
GTPase
Factor Xa
Liver X Receptor
MELK
Dipeptidyl Peptidase
Thyroid hormone receptor(THR)
NPC1L1
Kisspeptin
Myosin
Thioredoxin
Neprilysin
FOXO
Liposome
MIF
Neurotensin Receptor
Adenylate cyclase
GlyT
ASK
Methionine Adenosyltransferase (MAT)
Aquaporin
RAR/RXR
MALT
MyD88
Cadherin
GluCls
Pyroptosis
RXFP receptor
NADPH-oxidase
Advanced Glycation End Products
Cell wall
OCT
Hck
Stemness kinase
ACK1
Lipid
PSMA
BMI-1
MicroRNA
Cell Cycle Arrest
LIM Kinase
Glucokinase
PAFR
MTH1
HCAR
MNK
KLF
Hydrogenase
Factor VIIa
N-Acetylglucosaminyltransferase
ATG
Anion Exchanger
E3 Ligase Ligand-Linker Conjugates
Hippo pathway
Imidazoline Receptor
Ferroportin
Drug-Linker Conjugates for ADC
Vitamin

Keywords

AntiCancer Clinical Compound LibraryAnti Cancer Clinical Compound Library