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TargetMol | Compound Library

抗癌临床化合物库现货

Anti-Cancer Clinical Compound Library

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货号 L2120

尽管在过去的几十年中癌症的研究和治疗取得了巨大的成功，但癌症仍然是人类面临的巨大挑战，给患者身心健康带来巨大的痛苦。癌细胞具有许多显著不同的生物学特征，表现出无限的增殖潜能，维持自身生长信号的持续稳定，逃避应激信号(例如治疗药物)诱导的细胞凋亡，刺激血管生长，为肿瘤提供营养，同时逃避免疫系统防御和诱导局部慢性炎症，发挥其侵袭和转移能力，表现出异常的代谢活动，并通过突变和表观遗传机制显著改变全基因组的稳定性。

抗癌活性的药物是临床研究的热点之一，根据文献报道和有关公开资料，我们收集了2760 个具有抗癌活性或潜在抗癌活性的处于临床试验阶段的化合物，组成抗癌临床化合物库，可用于癌症相关研究及高通量高内涵筛选。

TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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货号 L2120

抗癌临床化合物库

规格

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
询价 & 定制

产品描述

  • 2760个具有抗癌活性小分子的独特集合，可用于高通量高内涵筛选；
  • 生物活性已经临床前实验证实，所有化合物均已进入临床实验阶段的抗癌化合物；
  • 包括肺癌、乳腺癌、白血病、淋巴瘤等15种癌症，是癌症相关研究的有效筛选工具；
  • 作用靶点涉及PI3K,HDAC, mTOR, CDK, JAK 等癌症相关靶点；
  • 结构多样，药效显著，可渗透细胞；
  • 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

包装和储存 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
  • 干粉蓝冰运输，DMSO溶液干冰运输；
  • 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
  • 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求，采用其他溶剂或浓度包装，具体以实际产品信息为准。

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Apoptosis
Autophagy
Endogenous Metabolite
5-HT Receptor
Antibacterial
Adrenergic Receptor
DNA/RNA Synthesis
Dopamine Receptor
Antibiotic
VEGFR
COX
Potassium Channel
Calcium Channel
Histamine Receptor
Sodium Channel
Parasite
EGFR
PI3K
ROS
CDK
Cytochromes P450
Reactive Oxygen Species
NF-κB
FLT
PDGFR
JAK
Glucocorticoid Receptor
HIV Protease
Topoisomerase
mTOR
FGFR
c-Kit
HDAC
Akt
c-Met/HGFR
Microtubule Associated
PPAR
Virus Protease
AChR
Ferroptosis
Prostaglandin Receptor
SARS-CoV
Src
Dehydrogenase
Nucleoside Antimetabolite/Analog
GABA Receptor
p38 MAPK
Antifungal
Mitophagy
Estrogen Receptor/ERR
Tyrosine Kinases
ERK
iGluR
Estrogen/progestogen Receptor
Adenosine Receptor
Caspase
Bcr-Abl
Interleukin
Androgen Receptor
Influenza Virus
Ras
GPCR
Raf
TNF
PARP
HSV
Epigenetic Reader Domain
HSP
Bcl-2 Family
Aurora Kinase
P-gp
Serotonin Transporter
PDE
TRP/TRPV Channel
MEK
MDM-2/p53
ALK
HBV
Opioid Receptor
Trk receptor
HIF/HIF Prolyl-Hydroxylase
HER
ATPase
RAAS
PKC
Mitochondrial Metabolism
STAT
c-RET
Norepinephrine
TLR
c-Fms
Histone Methyltransferase
HCV Protease
Phosphatase
NMDAR
AMPK
ROS Kinase
DNA Alkylator/Crosslinker
JNK
Wnt/beta-catenin
Endothelin Receptor
GSK-3
E1/E2/E3 Enzyme
MMP
Chk
TAM Receptor
FAK
Proton pump
LPL Receptor
Progesterone Receptor
Gamma-secretase
Drug Metabolite
Molecular Glues
Beta Amyloid
Retinoid Receptor
S1P Receptor
KRas
Guanylate cyclase
CXCR
GluR
IGF-1R
SGLT
Reverse Transcriptase
HIF
CFTR
p53
NO Synthase
Carbonic Anhydrase
DNA-PK
Antifolate
IL Receptor
TGF-beta/Smad
Nrf2
Proteasome
Antioxidant
PKA
ROCK
P2X Receptor
DNA Alkylation
Vasopressin Receptor
ATM/ATR
Syk
S6 Kinase
Transferase
ADC Cytotoxin
IAP
Hedgehog/Smoothened
Lipoxygenase
PLK
HMG-CoA Reductase
DHFR
Integrin
P2Y Receptor
GNRH Receptor
IDO
CSF-1R
Isocitrate Dehydrogenase (IDH)
Angiotensin-converting Enzyme (ACE)
Indoleamine 2,3-Dioxygenase (IDO)
MAPK
Sirtuin
Ligand for E3 Ligase
Anti-infection
Kinesin
Monoamine Oxidase
BTK
Mdm2
Glutathione Peroxidase
MRP
Leukotriene Receptor
MAO
RIP kinase
Antifection
PAK
OX Receptor
Casein Kinase
IκB/IKK
Cannabinoid Receptor
DNA Methyltransferase
IRAK
Histone Demethylase
Serine Protease
Smo
DNA
Antiviral
Phospholipase
Hydroxylase
Neurokinin receptor
Sigma receptor
PROTACs
Reductase
PERK
Tie-2
Pim
FXR
Glucagon Receptor
CCR
Ephrin Receptor
PD-1/PD-L1
IKZF
NADPH
Serine/threonin kinase
PYK2
DPP-4
Bradykinin Receptor
Cholinesterase (ChE)
Xanthine Oxidase
Telomerase
STING
GPCR19
CRFR
RSV
GHSR
Tyrosinase
Thrombin
NOD-like Receptor (NLR)
Chloride channel
CRM1
YAP
IFNAR
Melatonin Receptor
c-Myc
CaSR
Cholecystokinin Receptor
Photosensitizer
NAMPT
Glutaminase
Aryl Hydrocarbon Receptor
ABC Transporter
Na-K-Cl cotransporter
Glucosidase
Monoamine Transporter
Fatty Acid Synthase
Neuropeptide Y Receptor
Somatostatin
glycosidase
CaMK
DUB
Wee1
PGE Synthase
Aminopeptidase
GST
Aromatase
Oxytocin Receptor
CGRP Receptor
NOD
AhR
NOS
ROR
LTR
Rho
IRE1
Annexin A
MT Receptor
KSP
ATP Citrate Lyase
OXPHOS
BCRP
Beta-Secretase
OAT
Survivin
Free radical scavengers
transporter
Decarboxylase
FKBP
ribosome
Melanocortin Receptor
PDK
Adenosine Deaminase
Cuproptosis
Gap Junction Protein
Discoidin Domain Receptor (DDR)
Protease-activated Receptor
MLK
Monocarboxylate transporter
NEDD8
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
Arginase
Cell wall
Necroptosis
TOPK
VDA
Galectin
Cysteine Protease
RANKL/RANK
UGT
LDL
GRK
DNA gyrase
Hexokinase
PROTAC Linker
HCN Channel
Thrombopoietin Receptor
Acyltransferase
Porcupine
CD73
Histone Acetyltransferase
PAI-1
LPA Receptor
PI4K
SGK
Complement System
p97
Thyroid hormone receptor(THR)
Advanced Glycation End Products
MicroRNA
NPC1L1
Hydrogenase
RAR/RXR
MALT
MyD88
Factor VIIa
DYRK
MIF
GTPase
Factor Xa
OCT
Kisspeptin
N-Acetylglucosaminyltransferase
Hck
ATG
Liver X Receptor
LIM Kinase
Neurotensin Receptor
Glucokinase
Stemness kinase
Myosin
PAFR
MTH1
GlyT
Anion Exchanger
Thioredoxin
ACK1
HCAR
Cadherin
Lipid
Huntingtin
PSMA
MNK
GluCls
ASK
Pyroptosis
MELK
Methionine Adenosyltransferase (MAT)
Neprilysin
Hippo pathway
KLF
Aquaporin
FOXO
RXFP receptor
NADPH-oxidase
BMI-1
Imidazoline Receptor
Ferroportin
Vitamin
Drug-Linker Conjugates for ADC
PGC-1α

Keywords

AntiCancer Clinical Compound LibraryAnti Cancer Clinical Compound Library