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Anti-MBD1 Antibody (1J371)
还可以产品编号 TMAH-00740
别名 Protein containing methyl-CpG-binding domain 1, PCM1, Methyl-CpG-binding protein MBD1, Methyl-CpG-binding domain protein 1, MBD 1, CXXC-type zinc finger protein 3, CXXC3
Anti-MBD1 Antibody (1J371) 是一种抗体，靶向 MBD1。Anti-MBD1 Antibody (1J371) 可用于 ELISA, IF。
Anti-MBD1 Antibody (1J371)
Anti-MBD1 Antibody (1J371)
还可以产品编号 TMAH-00740 别名 Protein containing methyl-CpG-binding domain 1, PCM1, Methyl-CpG-binding protein MBD1, Methyl-CpG-binding domain protein 1, MBD 1, CXXC-type zinc finger protein 3, CXXC3
Anti-MBD1 Antibody (1J371) 是一种抗体，靶向 MBD1。Anti-MBD1 Antibody (1J371) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-MBD1 Antibody (1J371) is an antibody targeting MBD1. Anti-MBD1 Antibody (1J371) can be used in ELISA, IF. |
| 别名 | Protein containing methyl-CpG-binding domain 1, PCM1, Methyl-CpG-binding protein MBD1, Methyl-CpG-binding domain protein 1, MBD 1, CXXC-type zinc finger protein 3, CXXC3 |
| Ig Type | Rabbit IgG |
| 克隆号 | 1J371 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of MCF-7 cell with TMAH-00740 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 498-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| 应用 | ELISA, IF |
| 推荐剂量 | IF:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human MBD1 |
| 抗原种属 | Human |
| 基因ID | 4152 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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