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顶部生物活性储存和溶解信息计算器

Anti-MBD1 Antibody (1J371)

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产品编号 TMAH-00740

别名 Protein containing methyl-CpG-binding domain 1, PCM1, Methyl-CpG-binding protein MBD1, Methyl-CpG-binding domain protein 1, MBD 1, CXXC-type zinc finger protein 3, CXXC3

Anti-MBD1 Antibody (1J371) 是一种抗体，靶向 MBD1。Anti-MBD1 Antibody (1J371) 可用于 ELISA,IF。

Anti-MBD1 Antibody (1J371)

Anti-MBD1 Antibody (1J371)

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产品编号 TMAH-00740 别名 Protein containing methyl-CpG-binding domain 1, PCM1, Methyl-CpG-binding protein MBD1, Methyl-CpG-binding domain protein 1, MBD 1, CXXC-type zinc finger protein 3, CXXC3

Anti-MBD1 Antibody (1J371) 是一种抗体，靶向 MBD1。Anti-MBD1 Antibody (1J371) 可用于 ELISA,IF。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,180
5日内发货
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产品介绍

生物活性
产品描述
Anti-MBD1 Antibody (1J371) is an antibody targeting MBD1. Anti-MBD1 Antibody (1J371) can be used in ELISA,IF.
别名Protein containing methyl-CpG-binding domain 1, PCM1, Methyl-CpG-binding protein MBD1, Methyl-CpG-binding domain protein 1, MBD 1, CXXC-type zinc finger protein 3, CXXC3
Ig Type
Rabbit IgG
克隆号
1J371
交叉反应
Human
验证活性
Immunofluorescence staining of MCF-7 cell with TMAH-00740 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 498-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
应用ELISAIF
推荐剂量
IF:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Nucleus. Nucleus matrix. Nucleus speckle. Chromosome.
组织特异性Widely expressed.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human MBD1
抗原种属
Human
基因名称
MBD1
基因ID
4152
Uniprot ID
Q9UIS9
研究领域
Epigenetics and Nuclear Signaling
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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