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ARMET/MANF Protein, Human, Recombinant (hFc)

产品编号 TMPY-00028

别名: ARP, ARMET, mesencephalic astrocyte-derived neurotrophic factor

ARMET/MANF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is A8K878.

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ARMET/MANF Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 2,940		5日内发货

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生物活性	Testing in progress
产品描述	ARMET/MANF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is A8K878.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	A8K878
别名	ARP, ARMET, mesencephalic astrocyte-derived neurotrophic factor
蛋白构建	The Human MANF (NP_006001.4) (Met1-Leu182) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	44.9 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral midbrain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus, and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggests that it has important functions both under normal and pathological conditions in many tissue types.

参考文献

1. Shridhar V., et al., 1996, Oncogene 12:1931-1939. 2. Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569. 3. Petrova P., et al., 2003, J. Mol. Neurosci. 20:173-188. 4. Lindholm, P. et al., 2008, Mol Cell Neurosci. 39 (3):356-71. 5. Airavaara, M. et al., 2010, Exp Neurol. 225 (1):104-13.

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Keywords

ARMET/MANF Protein, Human, Recombinant (hFc) ARP ARMET mesencephalic astrocyte-derived neurotrophic factor recombinant recombinant-proteins proteins protein

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