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Anti-VDAC1 Antibody (5H960)
还可以产品编号 TMAH-01243
别名 YNL2441C, YNL055C, Voltage-dependent anion-selective channel protein 1, Voltage dependent anion selective channel protein 1, Voltage dependent anion channel 1, VDAC-1, VDAC, Porin 31HM, Porin 31HL, POR1, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, OMP2, N2441, Mitochondrial Porin, MGC111064, hVDAC1
Anti-VDAC1 Antibody (5H960) 是一种抗体，靶向 VDAC1。Anti-VDAC1 Antibody (5H960) 可用于 ELISA, WB, IHC。
Anti-VDAC1 Antibody (5H960)
Anti-VDAC1 Antibody (5H960)
还可以产品编号 TMAH-01243 别名 YNL2441C, YNL055C, Voltage-dependent anion-selective channel protein 1, Voltage dependent anion selective channel protein 1, Voltage dependent anion channel 1, VDAC-1, VDAC, Porin 31HM, Porin 31HL, POR1, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, OMP2, N2441, Mitochondrial Porin, MGC111064, hVDAC1
Anti-VDAC1 Antibody (5H960) 是一种抗体，靶向 VDAC1。Anti-VDAC1 Antibody (5H960) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-VDAC1 Antibody (5H960) is an antibody targeting VDAC1. Anti-VDAC1 Antibody (5H960) can be used in ELISA, WB, IHC. |
| 别名 | YNL2441C, YNL055C, Voltage-dependent anion-selective channel protein 1, Voltage dependent anion selective channel protein 1, Voltage dependent anion channel 1, VDAC-1, VDAC, Porin 31HM, Porin 31HL, POR1, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, OMP2, N2441, Mitochondrial Porin, MGC111064, hVDAC1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 5H960 |
| 交叉反应 | Human, Mouse, Rat |
| 验证活性 | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, Jurkat whole cell lysate, HL-60 whole cell lysate, LO2 whole cell lysate, Raji whole cell lysate, Rat heart tissue, Mouse brain tissue -All lanes: VDAC1 antibody at 0.7μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 31 KDa -Observed band size: 31 KDa 2. IHC image of TMAH-01243 diluted at 1:73.125 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. 3. IHC image of TMAH-01243 diluted at 1:73.125 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human VDAC1 |
| 抗原种属 | Human |
| 基因ID | 7416 |
| Uniprot ID | |
| 研究领域 | Tags & Cell Markers |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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