Amidepsin C is a cyclic depsipeptide compound structurally related to the romidepsin family of histone deacetylase inhibitors. Featuring a bicyclic thiodepsipeptide architecture containing a unique disulfide bridge, Amidepsin C is characterized by its ability to chelate zinc ions within the HDAC active site. Amidepsin C is employed in epigenetic research as a probe for studying class I HDAC inhibition and its effects on histone acetylation status, chromatin remodeling, and gene expression regulation.