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Anti-DYNLL1 Antibody (5G489) 是一种 Rabbit 抗体,靶向 DYNLL1。Anti-DYNLL1 Antibody (5G489) 可用于 WB,ICC/IF,IHC,IP。
Anti-DYNLL1 Antibody (5G489) 是一种 Rabbit 抗体,靶向 DYNLL1。Anti-DYNLL1 Antibody (5G489) 可用于 WB,ICC/IF,IHC,IP。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,480 | 5日内发货 | |
100 μL | ¥ 2,480 | 5日内发货 |
产品描述 | Anti-DYNLL1 Antibody (5G489) is a Rabbit antibody targeting DYNLL1. Anti-DYNLL1 Antibody (5G489) can be used in WB,ICC/IF,IHC,IP. |
别名 | Protein Inhibitor of Neuronal Nitric Oxide Synthase, PIN, HDLC1, DYNLL1, Dynein Light Chain LC8-Type 1, Dynein Light Chain 1 Cytoplasmic, DNCLC1, DNCL1, DLC8, DLC1, 8 kDa Dynein Light Chain |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. Western blot analysis of DYNLL1 on MCF-7 cells lysates using anti-DYNLL1 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-DYNLL1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat esophagus tissue using anti-DYNLL1 antibody. Counter stained with hematoxylin. 4. ICC staining DYNLL1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining DYNLL1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining DYNLL1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
应用 | |
推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. The highly conserved DYNLL proteins were originally identified as light chains for microtubule-based motor protein Dynein. In mammals there are two closely related isoforms expressed, DYNLL1 and DYNLL2 which share 93% sequence identity at the protein level. DYNLL1 (Dynein light chain 1) also designated, DLC8 or PIN (Protein inhibitor of neuronal nitric oxide synthase) has been identified as a protein that interacts with NOS1 resulting in NOS1 inhibition. Dimerization is required for NOS1 activity and DYNLL1 has been shown to destabilize the NOS1 dimer. Nitric oxide may be involved in several processes such as apoptosis, synaptogenesis and neuronal development; thus DYNLL1 is implicated in these processes as well. DYNLL1 is a ubiquitously expressed protein that exhibits high expression in testis and moderate expression in brain. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein |
Uniprot ID |
分子量 | Theoretical: 10 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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