Frizzled 6 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R9E9.
生物活性 | Testing in progress |
产品描述 | Frizzled 6 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R9E9. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-mFc |
蛋白编号 | A0A024R9E9 |
别名 | NDNC10, frizzled class receptor 6, FZ6, FZ-6, HFZ6 |
蛋白构建 | The Human FZD6 (NP_003497.2) (Met1-Val153) was expressed with the Fc region of Mouse IgG1 at the C-terminus. |
蛋白纯度 | > 90 % as determined by SDS-PAGE. |
分子量 | 42 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC). FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis. |
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Frizzled 6 Protein, Human, Recombinant (mFc) NDNC10 frizzled class receptor 6 HFZ 6 FZ6 NDNC-10 FZ 6 HFZ-6 FZ-6 NDNC 10 HFZ6 recombinant recombinant-proteins proteins protein