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Anti-CD3 epsilon/CD3e Antibody (8R486)
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产品编号 TMAH-00195
别名 TCRE, T3E, IMD18, CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e, CD3 ε, CD3 epsilon
Anti-CD3 epsilon/CD3e Antibody (8R486) 是一种抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (8R486) 可用于 ELISA, FCM。
Anti-CD3 epsilon/CD3e Antibody (8R486)
Anti-CD3 epsilon/CD3e Antibody (8R486)
还可以产品编号 TMAH-00195 别名 TCRE, T3E, IMD18, CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e, CD3 ε, CD3 epsilon
Anti-CD3 epsilon/CD3e Antibody (8R486) 是一种抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody (8R486) 可用于 ELISA, FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD3 epsilon/CD3e Antibody (8R486) is an antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (8R486) can be used in ELISA, FCM. |
| 别名 | TCRE, T3E, IMD18, CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e, CD3 ε, CD3 epsilon |
| Ig Type | Mouse IgG2a |
| 克隆号 | 8R486 |
| 交叉反应 | Human |
| 验证活性 | Overlay Peak curve showing JK cells surface stained with TMAH-00195 (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10, 006 events was performed. |
| 应用 | |
| 推荐剂量 | FCM:1:20-1:500. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CD3E Protein |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Immunology, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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