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Anti-E-Cadherin/Cadherin-1 Antibody (7W893)
还可以产品编号 TMAY-00460
Anti-E-Cadherin/Cadherin-1 Antibody (7W893) 是一种 Mouse 抗体，靶向 E-Cadherin/Cadherin-1。Anti-E-Cadherin/Cadherin-1 Antibody (7W893) 可用于 FCM。
Anti-E-Cadherin/Cadherin-1 Antibody (7W893)
Anti-E-Cadherin/Cadherin-1 Antibody (7W893)
还可以产品编号 TMAY-00460
Anti-E-Cadherin/Cadherin-1 Antibody (7W893) 是一种 Mouse 抗体，靶向 E-Cadherin/Cadherin-1。Anti-E-Cadherin/Cadherin-1 Antibody (7W893) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-E-Cadherin/Cadherin-1 Antibody (7W893) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (7W893) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 7W893 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of human E-cad(CD324) expression on MCF-7 cells. Cells were stained with purified anti-Human E-cad(CD324), then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human E-Cadherin / CDH1 / E-cad / CD324 (rh E-Cadherin / CDH1 / E-cad / CD324; NP_004351.1Met1-Ile707). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human E-Cadherin / CDH1 / E-cad / CD324 protein |
| 抗原种属 | Human |
| 研究领域 | Hemangioblast Markers, Tumor Suppressors |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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