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ECE2 Protein, Human, Recombinant (His)

产品编号 TMPY-01891

别名: endothelin converting enzyme 2, UNQ403/PRO740, KIAA0604

ECE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.2 kDa and the accession number is P0DPD8.

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ECE2 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
20 μg	￥ 2,530		5日内发货

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生物活性	Testing in progress
产品描述	ECE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.2 kDa and the accession number is P0DPD8.

种属	Human
表达系统	HEK293 Cells
标签	N-His
蛋白编号	P0DPD8
别名	endothelin converting enzyme 2, UNQ403/PRO740, KIAA0604
蛋白构建	The ectodomain of Human endothelin converting enzyme 2 isoform A (NP_055508.3) (Gly 199-Trp 883) was fused with a polyhistidine tag at the N-terminus.
蛋白纯度	> 93 % as determined by SDS-PAGE
分子量	80.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Endothelin-converting enzyme 2, also known as ECE-2, is a metalloprotease that possesses many properties consistent with it being a neuropeptide-processing enzyme. Endothelin-converting enzymes (ECEs) are the key enzymes in the endothelin (ET) biosynthesis that catalyze the conversion of big ET, the biologically inactive precursor of mature ET. Two enzymes, termed ECE-1 and ECE-2, have been molecularly identified. ECE-2 is found primarily in neural tissues, with high levels of expression in midbrain, cerebellum, hypothalamus, frontal cortex and spinal cord and moderate levels in hippocampus and striatum. ECE-2 is strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). ECE-2 converts big endothelin-1 to endothelin-1. It is involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. ECE-2 may limit beta-amyloid peptide accumulation in brain. It may also have methyltransferase activity. A comparison of residues around the cleavage site revealed that ECE-2 exhibits a unique cleavage site selectivity that is related to but distinct from that of ECE-1.

参考文献

1. Lorenzo M.-N.,et al.,(2001), Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. Biochim. Biophys. Acta 1522:46-52. 2. Muzny D.M.,et al., (2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198. 3. Nagase T.,et al.,(1998), Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.DNA Res. 5:31-39.

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Keywords

ECE2 Protein, Human, Recombinant (His) KIAA-0604 UNQ403/PRO-740 endothelin converting enzyme 2 UNQ403/PRO740 KIAA0604 UNQ403/PRO 740 KIAA 0604 recombinant recombinant-proteins proteins protein

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