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HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

产品编号 TMPY-00548

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

产品编号 TMPY-00548

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.

规格	价格	库存
100 μg	¥ 3,170	In stock
200 μg	¥ 5,610	5日内发货
500 μg	¥ 11,900	5日内发货

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产品信息

生物活性	Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus HGF at 2 μg/ml (100 μl/well) can bind Cynomolgus c-MET His , the EC50 of Cynomolgus c-MET His is 15-60 ng/mL.
产品描述	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
种属	Cynomolgus,Rhesus
表达系统	HEK293 Cells
标签	C-His
蛋白编号	G7MM61
别名	MET proto-oncogene, receptor tyrosine kinase
蛋白构建	A DNA sequence encoding the cynomolgus/rhesus MET (A0A2K5UM36-1 / NP_001162100.2) (Met1-Thr932) was expressed with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus MET sequences are identical. Predicted N terminal: Glu 25
蛋白纯度	≥ 95% as determined by SDS-PAGE. ≥90 % as determined by SEC-HPLC.
分子量	103.1 kDa (predicted); 128.2, 77.6 and 45.7 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy