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Anti-E-Selectin/CD62E Antibody (5C686)
还可以产品编号 TMAY-00641
Anti-E-Selectin/CD62E Antibody (5C686) 是一种 Rabbit 抗体，靶向 E-Selectin/CD62E。Anti-E-Selectin/CD62E Antibody (5C686) 可用于 ELISA,FCM。
Anti-E-Selectin/CD62E Antibody (5C686)
Anti-E-Selectin/CD62E Antibody (5C686)
还可以产品编号 TMAY-00641
Anti-E-Selectin/CD62E Antibody (5C686) 是一种 Rabbit 抗体，靶向 E-Selectin/CD62E。Anti-E-Selectin/CD62E Antibody (5C686) 可用于 ELISA,FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-E-Selectin/CD62E Antibody (5C686) is a Rabbit antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody (5C686) can be used in ELISA,FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5C686 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD62E expression on HUVEC cells. HUVEC cells were treated with TNF-α (50 ng/ml, 18 hours). Cells were stained with purified anti-Human CD62E, then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | ELISA,FCM |
| 推荐剂量 | ELISA: 1:5000-1:10000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human E-Selectin / CD62e (rh E-Selectin / CD62e; TMPY-01167; NP_000441.2; Met 1-Pro 556). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. Besides, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human E-Selectin / CD62e protein (TMPY-01167) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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