Anti-RET Antibody (8B538)

Name: Anti-RET Antibody (8B538)
Brand: TargetMol
SKU: TMAH-01039
Rating: 4.5 (1 reviews)

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产品编号 TMAH-01039

别名 RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12

Anti-RET Antibody (8B538) 是一种抗体，靶向 RET。Anti-RET Antibody (8B538) 可用于 ELISA, FCM。

Anti-RET Antibody (8B538)

还可以

产品编号 TMAH-01039 别名 RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12

Anti-RET Antibody (8B538) 是一种抗体，靶向 RET。Anti-RET Antibody (8B538) 可用于 ELISA, FCM。

规格	价格	库存	数量
50 μL	¥ 1,315	5日内发货
100 μL	¥ 2,195	5日内发货

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产品描述	Anti-RET Antibody (8B538) is an antibody targeting RET. Anti-RET Antibody (8B538) can be used in ELISA, FCM.
别名	RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12
Ig Type	Rabbit IgG
克隆号	8B538
交叉反应	Human
验证活性	Overlay histogram showing Hela cells stained with TMAH-01039 (red line) at 1:50. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/110^6 cells) for 45min at 4°C.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4°C. Control antibody (green line) was Rabbit IgG (1µg/110^6 cells) used under the same conditions. Acquisition of >10,000 events was performed.
应用	ELISA FCM
推荐剂量	FCM:1:20-1:200.
抗体种类	Monoclonal
亚细胞定位	Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways. Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL.