购物车
- 全部删除
- 您的购物车当前为空
Anti-EMMPRIN/CD147 Antibody (5N85) 是一种 Rabbit 抗体,靶向 EMMPRIN/CD147。Anti-EMMPRIN/CD147 Antibody (5N85) 可用于 ELISA,ICC/IF。
Anti-EMMPRIN/CD147 Antibody (5N85) 是一种 Rabbit 抗体,靶向 EMMPRIN/CD147。Anti-EMMPRIN/CD147 Antibody (5N85) 可用于 ELISA,ICC/IF。
产品描述 | Anti-EMMPRIN/CD147 Antibody (5N85) is a Rabbit antibody targeting EMMPRIN/CD147. Anti-EMMPRIN/CD147 Antibody (5N85) can be used in ELISA,ICC/IF. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 5N85 |
交叉反应 | Mouse |
验证活性 | Immunofluorescence staining of Mouse BSG in Mouse Spleen cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse BSG monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cell membrane. |
应用 | ELISA,ICC/IF |
推荐剂量 | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD147 (rM CD147; TMPY-01316; NP_001070652.1; Met 1-Arg 209). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers. |
偶联 | Unconjugated |
免疫原 | Recombinant Mouse CD147 protein (TMPY-01316) |
抗原种属 | Mouse |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
评论内容