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Anti-EMMPRIN/CD147 Antibody (5N85)

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产品编号 TMAY-03240

Anti-EMMPRIN/CD147 Antibody (5N85) 是一种 Rabbit 抗体,靶向 EMMPRIN/CD147。Anti-EMMPRIN/CD147 Antibody (5N85) 可用于 ELISA,ICC/IF。

Anti-EMMPRIN/CD147 Antibody (5N85)

Anti-EMMPRIN/CD147 Antibody (5N85)

Rating icon 还可以
产品编号 TMAY-03240

Anti-EMMPRIN/CD147 Antibody (5N85) 是一种 Rabbit 抗体,靶向 EMMPRIN/CD147。Anti-EMMPRIN/CD147 Antibody (5N85) 可用于 ELISA,ICC/IF。

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产品介绍

生物活性
产品描述
Anti-EMMPRIN/CD147 Antibody (5N85) is a Rabbit antibody targeting EMMPRIN/CD147. Anti-EMMPRIN/CD147 Antibody (5N85) can be used in ELISA,ICC/IF.
Ig Type
Monoclonal Rabbit IgG
克隆号
5N85
交叉反应
Mouse
验证活性
Immunofluorescence staining of Mouse BSG in Mouse Spleen cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse BSG monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cell membrane.
应用
ELISA,ICC/IF
推荐剂量
ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD147 (rM CD147; TMPY-01316; NP_001070652.1; Met 1-Arg 209).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Mouse CD147 protein (TMPY-01316)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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4个月前
5.0
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