Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1]. |
体外活性 | Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC 50 s of 1.6, 0.72, 7.07 μM for HepG2, A549, H596 cells, respectively [1]. Anticancer agent 47 (0.8, 1.6, 3.2 μM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase [1]. Anticancer agent 47 (5 μM; 5h) significantly increases ROS production [1]. Apoptosis Analysis [1] Cell Line: HepG2, H596 cells Concentration: 0.8, 1.6, 3.2 μM Incubation Time: 24 h Result: Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 μM in HepG2 cell, respectively. Cell Cycle Analysis [1] Cell Line: HepG2 cells Concentration: 0.8, 1.6, 3.2 μM Incubation Time: 24 h Result: Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 μM, respectively. |
体内活性 | Anticancer agent 47 (20 mg/kg; i.v.; once every 2 days for 19 days) shows antitumor activities [1]. Animal Model: BALB/c nude mice (HepG2 xenografts) [1] Dosage: 20 mg/kg Administration: I.v.; once every 2 days for 19 days Result: Effectively inhibited tumor growth with the 58.7% tumor inhibition rate. |
分子量 | 366.39 |
分子式 | C19H14N2O4S |
CAS No. | 2461795-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Anticancer agent 47 2461795-23-1 Inhibitor inhibitor inhibit