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Anti-TNFSF11 Monoclonal Antibody (1K503)

Synonyms: TRANCE, TNLG6B, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
货号 TMAT-0599 一键复制产品信息
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Anti-TNFSF11 Monoclonal Antibody (1K503) 是一种 Mouse 抗体，靶向 TNFSF11。Anti-TNFSF11 Monoclonal Antibody (1K503) 可用于 WB,IHC,IF,FCM。

Anti-TNFSF11 Monoclonal Antibody (1K503)

一键复制产品信息
Rating icon 还可以
货号 TMAT-0599

别名 TRANCE, TNLG6B, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254

Anti-TNFSF11 Monoclonal Antibody (1K503) 是一种 Mouse 抗体，靶向 TNFSF11。Anti-TNFSF11 Monoclonal Antibody (1K503) 可用于 WB,IHC,IF,FCM。

Anti-TNFSF11 Monoclonal Antibody (1K503)
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产品介绍

生物活性
产品描述
Anti-TNFSF11 Monoclonal Antibody (1K503) is a Mouse antibody targeting TNFSF11. Anti-TNFSF11 Monoclonal Antibody (1K503) can be used in WB,IHC,IF,FCM.
别名
TRANCE, TNLG6B, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Ig Type
IgG1
克隆号
1K503
反应种属
Human,Mouse,Rat,Monkey,Rabbit
应用WBIHCIFFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/100-1/500; IF: 1/50-1/500; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human TNFSF11 (AA: 74-308) expressed in E. Coli.
抗原种属
Human
基因名称
TNFSF11
基因ID
8600
蛋白名称
Tumor necrosis factor ligand superfamily member 11
Uniprot ID
O14788
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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