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Anti-HER4/ERBB4 Antibody (8W756)

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Anti-HER4/ERBB4 Antibody (8W756)
产品编号 TMAC-01813
别名 Tyrosine kinase-type cell surface receptor HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, p180erbB4

Anti-HER4/ERBB4 Antibody (8W756) 是一种 Mouse 抗体，靶向 HER4/ERBB4。Anti-HER4/ERBB4 Antibody (8W756) 可用于 WB,IP,IF,IHC-P,FCM。

Anti-HER4/ERBB4 Antibody (8W756)

Anti-HER4/ERBB4 Antibody (8W756)

Rating icon 还可以
Anti-HER4/ERBB4 Antibody (8W756)
产品编号 TMAC-01813 别名 Tyrosine kinase-type cell surface receptor HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, p180erbB4

Anti-HER4/ERBB4 Antibody (8W756) 是一种 Mouse 抗体，靶向 HER4/ERBB4。Anti-HER4/ERBB4 Antibody (8W756) 可用于 WB,IP,IF,IHC-P,FCM。

规格价格库存数量
50 μL
¥ 1,985
5日内发货
100 μL
¥ 2,990
5日内发货
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产品介绍

生物活性
产品描述
Anti-HER4/ERBB4 Antibody (8W756) is a Mouse antibody targeting HER4/ERBB4. Anti-HER4/ERBB4 Antibody (8W756) can be used in WB,IP,IF,IHC-P,FCM.
别名Tyrosine kinase-type cell surface receptor HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, p180erbB4
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of ErbB-4 expression in control (A) and ErbB-4 transfected (B) NIH/3T3 whole cell lysates.
2. Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and ErbB-4 transfected (solid orange histogram) NIH/3T3 cells. Dotted pink histogram represents the isotype control, normal mouse IgG2a.
应用
WB
IP
IF
IHC-P
FCM
推荐剂量
WB: 1:100-1000; IHC-P: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate); FCM: 1 μg per 1 x 106 cells
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Amino acids 1280-1308 at C-terminus of ErbB-4 of human origin
抗原种属
human
Uniprot ID
Q15303
化学信息
分子量Theoretical: 180 kDa.
存储&运输
储存方式Store at 2°C-8°C for 12 months, do not freeze.
运输方式Shipping with blue ice.

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