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Anti-GRO beta/CXCL2 Antibody (7T64)
还可以产品编号 TMAY-00995
Anti-GRO beta/CXCL2 Antibody (7T64) 是一种 Mouse 抗体，靶向 GRO beta/CXCL2。Anti-GRO beta/CXCL2 Antibody (7T64) 可用于 ELISA。
Anti-GRO beta/CXCL2 Antibody (7T64)
Anti-GRO beta/CXCL2 Antibody (7T64)
还可以产品编号 TMAY-00995
Anti-GRO beta/CXCL2 Antibody (7T64) 是一种 Mouse 抗体，靶向 GRO beta/CXCL2。Anti-GRO beta/CXCL2 Antibody (7T64) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-GRO beta/CXCL2 Antibody (7T64) is a Mouse antibody targeting GRO beta/CXCL2. Anti-GRO beta/CXCL2 Antibody (7T64) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 7T64 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CXCL2/MIP-2 (rh CXCL2/MIP-2; TMPY-00006; NP_002080.1; Ala35-Asn107). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CXCL2/MIP-2 Protein (TMPY-00006) |
| 抗原种属 | Human |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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