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Anti-RIM 2 Antibody (5F972)
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产品编号 TMAC-03606
别名 RIMS2_HUMAN, Rims2 (gene name), Rims2, RIM2, Regulating synaptic membrane exocytosis protein 2, Regulating synaptic membrane exocytosis 2, RAB3IP3, Rab-3-interacting protein 3, Rab-3-interacting molecule 2, Rab3 interacting molecule 2, Protein regulating synaptic membrane exocytosis 2, OBOE, Non small cell lung cancer RimL3c protein, Non small cell lung cancer RimL3a protein, KIAA0751
Anti-RIM 2 Antibody (5F972) 是一种 Mouse 抗体，靶向 RIM 2。Anti-RIM 2 Antibody (5F972) 可用于 WB,IP。
Anti-RIM 2 Antibody (5F972)
Anti-RIM 2 Antibody (5F972)
还可以产品编号 TMAC-03606 别名 RIMS2_HUMAN, Rims2 (gene name), Rims2, RIM2, Regulating synaptic membrane exocytosis protein 2, Regulating synaptic membrane exocytosis 2, RAB3IP3, Rab-3-interacting protein 3, Rab-3-interacting molecule 2, Rab3 interacting molecule 2, Protein regulating synaptic membrane exocytosis 2, OBOE, Non small cell lung cancer RimL3c protein, Non small cell lung cancer RimL3a protein, KIAA0751
Anti-RIM 2 Antibody (5F972) 是一种 Mouse 抗体，靶向 RIM 2。Anti-RIM 2 Antibody (5F972) 可用于 WB,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,990 | 5日内发货 | |
| 100 μL | ¥ 2,980 | 5日内发货 |
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| 产品描述 | Anti-RIM 2 Antibody (5F972) is a Mouse antibody targeting RIM 2. Anti-RIM 2 Antibody (5F972) can be used in WB,IP. |
| 别名 | RIMS2_HUMAN, Rims2 (gene name), Rims2, RIM2, Regulating synaptic membrane exocytosis protein 2, Regulating synaptic membrane exocytosis 2, RAB3IP3, Rab-3-interacting protein 3, Rab-3-interacting molecule 2, Rab3 interacting molecule 2, Protein regulating synaptic membrane exocytosis 2, OBOE, Non small cell lung cancer RimL3c protein, Non small cell lung cancer RimL3a protein, KIAA0751 |
| 交叉反应 | Human,Rat |
| 验证活性 | 1. Western blot analysis of Rim2 expression in PC-12 whole cell lysate. |
| 应用 | |
| 推荐剂量 | WB: 1:100-1000; IHC: 1:50-500; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis. Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an N-terminal zinc-finger motif and C-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing. The 3’-end of the Rim2 gene produces an independent mRNA that encodes a smaller protein referred to as Nim2, which like Rim, also regulates exocytosis. Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles. Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis. Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion. |
| 偶联 | Unconjugated |
| 免疫原 | Peptide |
| Uniprot ID |
| 分子量 | Theoretical: 160 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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