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Anti-Nicastrin Antibody (4R415)
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产品编号 TMAC-02847
别名 RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2
Anti-Nicastrin Antibody (4R415) 是一种 Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody (4R415) 可用于 WB。
Anti-Nicastrin Antibody (4R415)
Anti-Nicastrin Antibody (4R415)
还可以产品编号 TMAC-02847 别名 RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2
Anti-Nicastrin Antibody (4R415) 是一种 Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody (4R415) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB. |
| 别名 | RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of Nicastrin on THP-1 cell lysate using anti-Nicastrin antibody at 1/1,000 dilution. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites. |
| 偶联 | Unconjugated |
| 免疫原 | A synthesized peptide: within Human Nicastrin aa 650-750 (C terminal) |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 78 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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