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顶部生物活性储存和溶解信息计算器

Anti-Nicastrin Antibody (4R415)

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产品编号 TMAC-02847

别名 RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2

Anti-Nicastrin Antibody (4R415) 是一种 Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody (4R415) 可用于 WB。

Anti-Nicastrin Antibody (4R415)

Anti-Nicastrin Antibody (4R415)

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Rating icon 还可以
产品编号 TMAC-02847 别名 RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2

Anti-Nicastrin Antibody (4R415) 是一种 Rabbit 抗体，靶向 Nicastrin。Anti-Nicastrin Antibody (4R415) 可用于 WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Nicastrin Antibody (4R415) is a Rabbit antibody targeting Nicastrin. Anti-Nicastrin Antibody (4R415) can be used in WB.
别名RP11-517F10.1, nicastrin, NCSTN, KIAA0253, ATAG1874, APH2
Ig Type
IgG
克隆号
4R415
交叉反应
Human
验证活性
1. Western blot analysis of Nicastrin on THP-1 cell lysate using anti-Nicastrin antibody at 1/1,000 dilution.
verifiedActivity
应用WB
推荐剂量
WB: 1:500-1000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthesized peptide: within Human Nicastrin aa 650-750 (C terminal)
抗原种属
human
Uniprot ID
Q92542
化学信息
分子量Theoretical: 78 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

KIAA-0253KIAA 0253ATAG-1874ATAG 1874APH-2APH 2

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4个月前
5.0
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