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Anti-E-Selectin/CD62E Antibody-APC (3G801)
还可以产品编号 TMAY-00639A
Anti-E-Selectin/CD62E Antibody-APC (3G801) 是一种 APC-conjugated Mouse 抗体，靶向 E-Selectin/CD62E。Anti-E-Selectin/CD62E Antibody-APC (3G801) 可用于 FCM。
Anti-E-Selectin/CD62E Antibody-APC (3G801)
Anti-E-Selectin/CD62E Antibody-APC (3G801)
还可以产品编号 TMAY-00639A
Anti-E-Selectin/CD62E Antibody-APC (3G801) 是一种 APC-conjugated Mouse 抗体，靶向 E-Selectin/CD62E。Anti-E-Selectin/CD62E Antibody-APC (3G801) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-E-Selectin/CD62E Antibody-APC (3G801) is a APC-conjugated Mouse antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody-APC (3G801) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 3G801 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD62E in HUVEC cells. HUVEC cells (Human umbilical vein endothelial cells) were treated with TNF-α (50 ng/ml, 18 hours). The cells were harvested and stained with APC-conjugated anti-Human CD62E. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human E-Selectin/CD62e/SELE (rh E-Selectin/CD62e/SELE; TMPY-01167; NP_000441.2; Met1-Pro556) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. Besides, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human E-Selectin/CD62e/SELE Protein (TMPY-01167) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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