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IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc)

产品编号 TMPY-00755

别名: chemokine (C-X-C motif) ligand 8, Interleukin-8, LYNAP, NAP1, NAF, IL-8, 白介素, GCP-1, MONAP, MDNCF, NAP-1, GCP1, LUCT, IL8, LECT, 白细胞介素

IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35 kDa and the accession number is A0A024RDA5.

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IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,430		5日内发货

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生物活性	Testing in progress
产品描述	IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35 kDa and the accession number is A0A024RDA5.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	A0A024RDA5
别名	chemokine (C-X-C motif) ligand 8, Interleukin-8, LYNAP, NAP1, NAF, IL-8, 白介素, GCP-1, MONAP, MDNCF, NAP-1, GCP1, LUCT, IL8, LECT, 白细胞介素
蛋白构建	The 72 amino acid residue form (Ser 28-Ser 99) of mature Human IL8 (NP_000575.1) was fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	35 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL1, TNF, LPS, etc). In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Interleukin (IL)-8/CXCL8 is a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. However, several lines of evidence indicate that IL-8/CXCL8 has a wide range of actions on various types of cells, including lymphocytes, monocytes, endothelial cells, and fibroblasts, besides neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression.

参考文献

1. Mukaida N. (2003) Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 284(4): L566-77. 2. Brat DJ,et al.(2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 7(2): 122-33. 3. Bendrik C,et al.(2009) Estradiol increases IL-8 secretion of normal human breast tissue and breast cancer in vivo. J Immunol. 182(1): 371-8.

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Keywords

IL-8/CXCL8 Protein, Human, Recombinant (aa 28-99, hFc) chemokine (C-X-C motif) ligand 8 Interleukin-8 LYNAP NAP1 NAF IL-8 白介素 IL 8 GCP-1 MONAP NAP 1 MDNCF GCP 1 NAP-1 GCP1 LUCT IL8 LECT 白细胞介素 recombinant recombinant-proteins proteins protein

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