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Anti-Phospho-PERK(Thr981) Antibody (7J51)
还可以产品编号 TMAH-00940
别名 WRS, PRKR like endoplasmic reticulum kinase, p-PERK(Thr981), p-PERK(T981), Phospho-PERK(T981), PERK(p-Thr981), PERK(p-T981), PEK, Pancreatic eIF2-alpha kinase, Pancreatic eIF2 alpha kinase, HsPEK, HRI, Heme regulated EIF2 alpha kinase, Eukaryotic translation initiation factor 2 alpha kinase 3, Eif2ak3, EC 2.7.11.1, E2AK3_HUMAN, DKFZp781H1925
Anti-Phospho-PERK(Thr981) Antibody (7J51) 是一种 Mouse 抗体，靶向 Phospho-PERK(Thr981)。Anti-Phospho-PERK(Thr981) Antibody (7J51) 可用于 ELISA, IF。
Anti-Phospho-PERK(Thr981) Antibody (7J51)
Anti-Phospho-PERK(Thr981) Antibody (7J51)
还可以产品编号 TMAH-00940 别名 WRS, PRKR like endoplasmic reticulum kinase, p-PERK(Thr981), p-PERK(T981), Phospho-PERK(T981), PERK(p-Thr981), PERK(p-T981), PEK, Pancreatic eIF2-alpha kinase, Pancreatic eIF2 alpha kinase, HsPEK, HRI, Heme regulated EIF2 alpha kinase, Eukaryotic translation initiation factor 2 alpha kinase 3, Eif2ak3, EC 2.7.11.1, E2AK3_HUMAN, DKFZp781H1925
Anti-Phospho-PERK(Thr981) Antibody (7J51) 是一种 Mouse 抗体，靶向 Phospho-PERK(Thr981)。Anti-Phospho-PERK(Thr981) Antibody (7J51) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Phospho-PERK(Thr981) Antibody (7J51) is a Mouse antibody targeting Phospho-PERK(Thr981). Anti-Phospho-PERK(Thr981) Antibody (7J51) can be used in ELISA, IF. |
| 别名 | WRS, PRKR like endoplasmic reticulum kinase, p-PERK(Thr981), p-PERK(T981), Phospho-PERK(T981), PERK(p-Thr981), PERK(p-T981), PEK, Pancreatic eIF2-alpha kinase, Pancreatic eIF2 alpha kinase, HsPEK, HRI, Heme regulated EIF2 alpha kinase, Eukaryotic translation initiation factor 2 alpha kinase 3, Eif2ak3, EC 2.7.11.1, E2AK3_HUMAN, DKFZp781H1925 |
| Ig Type | IgG1 |
| 克隆号 | 7J51 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunofluorescence staining of A549 cells with TMAH-00940 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L). 2. Immunofluorescence staining of Hela cells with TMAH-00940 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L). 3. Immunofluorescence staining of U87 cells with TMAH-00940 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L). |
| 应用 | ELISA, IF |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein G purified |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 纯度 | >95% |
| 研究背景 | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Eukaryotic translation initiation factor 2-alpha kinase 3 Protein (115-330AA) |
| 抗原种属 | Human |
| 基因ID | 9451 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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