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Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 2

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Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 2
产品编号 TMAC-00958
别名 RAF1 (p-Thr269), RAF1 (p-T269), p-RAF1 (Thr269), p-RAF1 (T269), Phospho-RAF1 (T269)

Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (Thr269)。Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 可用于 IHC。

Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 2

Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 2
产品编号 TMAC-00958 别名 RAF1 (p-Thr269), RAF1 (p-T269), p-RAF1 (Thr269), p-RAF1 (T269), Phospho-RAF1 (T269)

Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (Thr269)。Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody 可用于 IHC。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RAF1 (Thr269). Anti-Phospho-RAF1 (Thr269) Polyclonal Antibody can be used in IHC.
别名RAF1 (p-Thr269), RAF1 (p-T269), p-RAF1 (Thr269), p-RAF1 (T269), Phospho-RAF1 (T269)
Ig Type
IgG
交叉反应
Human,Mouse
验证活性
1. Immunohistochemical analysis of paraffin-embedded human brain tissue using C-RAF (Phospho-Thr269) antibody TMAC-00958 (left) or the same antibody preincubated with blocking peptide (right).
应用
IHC
推荐剂量
IHC: 1:50-100
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of threonine269 (S-T-T(p)-L-P) derived from Human C-RAF
抗原种属
human
Uniprot ID
P04049
化学信息
分子量Actual: 73 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

RAF1 (pThr269)RAF1 (pT269)RAF1 (phospho-Thr269)RAF1 (phospho-T269)Raf-1RAF1RAF proto-oncogene Thrine/threonine-protein kinaseRAF 1RAFProto-oncogene c-RAF (cRaf)pRAF1 (Thr269)pRAF1 (T269)c-RafcRaf

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