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Anti-CD3 epsilon/CD3e Antibody-PE (6O384)
还可以产品编号 TMAY-01395P
Anti-CD3 epsilon/CD3e Antibody-PE (6O384) 是一种 PE-conjugated Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody-PE (6O384) 可用于 FCM。
Anti-CD3 epsilon/CD3e Antibody-PE (6O384)
Anti-CD3 epsilon/CD3e Antibody-PE (6O384)
还可以产品编号 TMAY-01395P
Anti-CD3 epsilon/CD3e Antibody-PE (6O384) 是一种 PE-conjugated Mouse 抗体，靶向 CD3 epsilon/CD3e。Anti-CD3 epsilon/CD3e Antibody-PE (6O384) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-CD3 epsilon/CD3e Antibody-PE (6O384) is a PE-conjugated Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody-PE (6O384) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 6O384 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD3 expression on human peripheral blood lymphocytes. Cells were stained with PE-conjugated anti-Human CD3 and APC conjugated anti-Human CD19 (BD Pharmingen™ Cat. No. 555415). The dot plots were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 1 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/PerCP/FITC |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human CD3e / CD3 epsilon protein (TMPY-01191) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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