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Anti-Tim-4/TIMD4 Antibody (3X588)
还可以产品编号 TMAY-02256
Anti-Tim-4/TIMD4 Antibody (3X588) 是一种 Rabbit 抗体，靶向 Tim-4/TIMD4。Anti-Tim-4/TIMD4 Antibody (3X588) 可用于 ELISA。
Anti-Tim-4/TIMD4 Antibody (3X588)
Anti-Tim-4/TIMD4 Antibody (3X588)
还可以产品编号 TMAY-02256
Anti-Tim-4/TIMD4 Antibody (3X588) 是一种 Rabbit 抗体，靶向 Tim-4/TIMD4。Anti-Tim-4/TIMD4 Antibody (3X588) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Tim-4/TIMD4 Antibody (3X588) is a Rabbit antibody targeting Tim-4/TIMD4. Anti-Tim-4/TIMD4 Antibody (3X588) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3X588 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human TIM4 (rh TIM4; TMPY-02124; AAH08988.1; Met1-Leu315). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | A type I transmembrane protein called TIM4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIMD4), which belongs to the immunoglobulin superfamily and TIM family. TIM4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1/TIMD1. Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4, which is expressed on dendritic cells and macrophages, plays an important role in the initiation of T(H)2 polarization. TIM4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy. The interaction of TIM1/TIM4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIM4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Specific immunotherapy (SIT) suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIM4 in antigen-specific Th2 cells. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human TIM4 protein (TMPY-02124) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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