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Anti-Vav2 Antibody (1D552)

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Anti-Vav2 Antibody (1D552)
产品编号 TMAC-04225
别名 VAV2_HUMAN, VAV2 oncogene, Vav 2 oncogene, VAV 2, Protein vav 2, Oncogene VAV2, Guanine nucleotide exchange factor VAV2

Anti-Vav2 Antibody (1D552) 是一种 Rabbit 抗体,靶向 Vav2。Anti-Vav2 Antibody (1D552) 可用于 WB,ICC,IHC,IP。

Anti-Vav2 Antibody (1D552)

Anti-Vav2 Antibody (1D552)

Rating icon 还可以
Anti-Vav2 Antibody (1D552)
产品编号 TMAC-04225 别名 VAV2_HUMAN, VAV2 oncogene, Vav 2 oncogene, VAV 2, Protein vav 2, Oncogene VAV2, Guanine nucleotide exchange factor VAV2

Anti-Vav2 Antibody (1D552) 是一种 Rabbit 抗体,靶向 Vav2。Anti-Vav2 Antibody (1D552) 可用于 WB,ICC,IHC,IP。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-Vav2 Antibody (1D552) is a Rabbit antibody targeting Vav2. Anti-Vav2 Antibody (1D552) can be used in WB,ICC,IHC,IP.
别名VAV2_HUMAN, VAV2 oncogene, Vav 2 oncogene, VAV 2, Protein vav 2, Oncogene VAV2, Guanine nucleotide exchange factor VAV2
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of VAV2 on SW480 cells lysates using anti-VAV2 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-VAV2 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-VAV2 antibody. Counter stained with hematoxylin.
4. ICC staining VAV2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining VAV2 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. ICC staining VAV2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
推荐剂量
WB: 1:1000-5000; IHC: 1:50-200; ICC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. This protein, known as Vav, Vav1 or p95Vav, contains an N-terminal helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins that, if deleted, causes oncogenic activation. In addition, Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages. These results suggest that Vav may represent a new type of signal transduction molecule involved in the transduction of tyrosine phosphorylation signaling into transcriptional events. Vav2 is a member of the Vav family of oncoproteins and acts as a guanosine nucleotide exchange factor (GEF) for RhoG and RhoA-like GTPases in a phosphotyrosine-dependent manner.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
化学信息
分子量Theoretical: 100 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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