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Anti-E-Selectin/CD62E Antibody (1Y402) 是一种 Mouse 抗体，靶向 E-Selectin/CD62E。Anti-E-Selectin/CD62E Antibody (1Y402) 可用于 ELISA。
还可以Anti-E-Selectin/CD62E Antibody (1Y402) 是一种 Mouse 抗体，靶向 E-Selectin/CD62E。Anti-E-Selectin/CD62E Antibody (1Y402) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
| 产品描述 | Anti-E-Selectin/CD62E Antibody (1Y402) is a Mouse antibody targeting E-Selectin/CD62E. Anti-E-Selectin/CD62E Antibody (1Y402) can be used in ELISA. |
| 别名 | selectin E, LECAM2, ESEL, ELAM1, ELAM, CD62E |
| Ig Type | Mouse IgG1 |
| 克隆号 | 1Y402 |
| 交叉反应 | Cynomolgus |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Cynomolgus E-Selectin / CD62e / SELE ( TMPY-03519; G8F370; Met1-Pro556). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. Besides, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Cynomolgus E-Selectin / CD62e / SELE Protein (TMPY-03519) |
| 抗原种属 | Cynomolgus |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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