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Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277)
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还可以产品编号 TMAB-01661
别名 奥密克戎（Omicron）, Surface glycoprotein(WT & Omicron), SPIKE_SARS2, Spike protein S1, Spike protein RBD(WT & Omicron), Spike glycoprotein(WT & Omicron), SARS冠状病毒2 RBD (WT & Omicron), SARS-CoV-2 spike protein(WT & Omicron), SARS-CoV-2 Spike protein RBD(WT & Omicron), COVID-19 Spike protein RBD(WT & Omicron), 2019-nCOV Spike protein(WT & Omicron)
Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277) 是一种 Mouse 抗体，靶向 SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron)。Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277) 可用于 ELISA。
Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277)
Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277)
一键复制产品信息 还可以产品编号 TMAB-01661 别名 奥密克戎（Omicron）, Surface glycoprotein(WT & Omicron), SPIKE_SARS2, Spike protein S1, Spike protein RBD(WT & Omicron), Spike glycoprotein(WT & Omicron), SARS冠状病毒2 RBD (WT & Omicron), SARS-CoV-2 spike protein(WT & Omicron), SARS-CoV-2 Spike protein RBD(WT & Omicron), COVID-19 Spike protein RBD(WT & Omicron), 2019-nCOV Spike protein(WT & Omicron)
Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277) 是一种 Mouse 抗体，靶向 SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron)。Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μg | ¥ 3,580 | 5日内发货 |
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| 产品描述 | Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277) is a Mouse antibody targeting SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron). Anti-SARS-CoV-2 (2019-nCoV) Spike RBD (WT & Omicron) Antibody (5L277) can be used in ELISA. |
| 别名 | 奥密克戎（Omicron）, Surface glycoprotein(WT & Omicron), SPIKE_SARS2, Spike protein S1, Spike protein RBD(WT & Omicron), Spike glycoprotein(WT & Omicron), SARS冠状病毒2 RBD (WT & Omicron), SARS-CoV-2 spike protein(WT & Omicron), SARS-CoV-2 Spike protein RBD(WT & Omicron), COVID-19 Spike protein RBD(WT & Omicron), 2019-nCOV Spike protein(WT & Omicron) |
| Ig Type | IgG2a |
| 克隆号 | 5L277 |
| 交叉反应 | SARS-CoV-2 |
| 验证活性 | Direct ELISA was used to detect the binding ability of anti-RBD monoclonal antibody to RBD domain proteins of different SARS-CoV-2 Mutant Strains. Immobilized SARS-CoV-2 RBD proteins, at 2 μg/ml (100ul/Well) can bind Anti-RBD monoclonal antibody-HRP at 1 μg/ml (100ul/Well).  |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion. |
| 组织特异性 | The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease t |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M PBS (pH7.4). |
| 浓度 | Lot Dependent |
| 研究背景 | The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct. |
| 免疫原 | Recombinant Protein: SARS-CoV-2 Spike S1 Protein |
| 基因名称 | S |
| 蛋白名称 | Spike glycoprotein |
| 研究领域 | SARS Coronavirus |
| 功能 | attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. |
| 分子量 | Theoretical: 140 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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