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Anti-VCAM-1 Antibody (5T238)
还可以产品编号 TMAY-03150
别名 VCAM-1, vascular cell adhesion molecule 1, INCAM-100, CD106
Anti-VCAM-1 Antibody (5T238) 是一种 Rabbit 抗体，靶向 VCAM-1。Anti-VCAM-1 Antibody (5T238) 可用于 WB,FCM。
Anti-VCAM-1 Antibody (5T238)
Anti-VCAM-1 Antibody (5T238)
还可以产品编号 TMAY-03150 别名 VCAM-1, vascular cell adhesion molecule 1, INCAM-100, CD106
Anti-VCAM-1 Antibody (5T238) 是一种 Rabbit 抗体，靶向 VCAM-1。Anti-VCAM-1 Antibody (5T238) 可用于 WB,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-VCAM-1 Antibody (5T238) is a Rabbit antibody targeting VCAM-1. Anti-VCAM-1 Antibody (5T238) can be used in WB,FCM. |
| 别名 | VCAM-1, vascular cell adhesion molecule 1, INCAM-100, CD106 |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5T238 |
| 交叉反应 | Mouse |
| 验证活性 | 1. Anti-VCAM1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: NIH 3T3 Whole Cell Lysate. -Lane B: Mouse brain tissue Lysate. -Lane C: Mouse kidney tissue lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:81 kDa. -Observed band size:100 kDa. 2. Flow cytometric analysis of Mouse VCAM1(CD106) expression on BABL/c bone marrow cells. Cells were stained with purified anti-Mouse VCAM1(CD106), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | WB,FCM |
| 推荐剂量 | WB: 1:500-1:2000; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse VCAM1/VCAM-1/CD106 (rM VCAM1/VCAM-1/CD106; TMPY-01830; NP_035823.3; Met1-Glu698). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | FITC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse VCAM1/VCAM-1/CD106 Protein (TMPY-01830) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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