ATC0175 is a potent, selective, and orally active antagonist of the melanin-concentrating hormone 1 receptor (MCH1R), with IC50 values of 13.5 nM for MCH1R and greater than 10,000 nM for MCH2R, demonstrating antidepressant and anxiolytic effects in animal models and providing strong experimental relevance for depression and anxiety disorder research.

MCH2R:>10000 nM, MCH1R:13.5 nM

DMSO: 10 mg/mL (23.5 mM), Sonication is recommended.