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Anti-COMMD9 Antibody (8O554)
还可以产品编号 TMAY-02753
Anti-COMMD9 Antibody (8O554) 是一种 Mouse 抗体，靶向 COMMD9。Anti-COMMD9 Antibody (8O554) 可用于 ELISA,ICC/IF。
Anti-COMMD9 Antibody (8O554)
Anti-COMMD9 Antibody (8O554)
还可以产品编号 TMAY-02753
Anti-COMMD9 Antibody (8O554) 是一种 Mouse 抗体，靶向 COMMD9。Anti-COMMD9 Antibody (8O554) 可用于 ELISA,ICC/IF。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-COMMD9 Antibody (8O554) is a Mouse antibody targeting COMMD9. Anti-COMMD9 Antibody (8O554) can be used in ELISA,ICC/IF. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 8O554 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of COMMD9 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-human COMMD9 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green). Positive staining was localized to Cytoplasm and nucleus. |
| 应用 | ELISA,ICC/IF |
| 推荐剂量 | ELISA: 1:1000-1:2000; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human COMMD9 (rh COMMD9; TMPY-03505; Q9P000-1; Met1-Lys198). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. COMMD protein functions in the control of the transcription factor NFkappaB. NFkappaB plays a critical role in a number of homeostatic processes in multicellular organisms, including the regulation of immunity and cell survival. COMMD proteins inhibit NFkappaB mediated gene expression, and recent mechanistic studies have revealed that COMMD1 controls the ubiquitination of NFkappaB subunits, an event linked to transcriptional termination. COMMD1 binds to a multimeric ubiquitin ligase containing Elongins B/C, Cul2 and SOCS1 (ECS( SOCS1)). In this complex, COMMD1 facilitates the binding of NFkappaB subunits to the ligase, thereby promoting their ubiquitination and degradation. Additional insights gained from these studies indicate that COMMD proteins likely play a broader role in cellular homeostasis through their participation in the ubiquitination pathway. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human COMMD9 Protein (TMPY-03505) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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