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Anti-E-Cadherin/Cadherin-1 Antibody (8U274)
还可以产品编号 TMAY-00462
Anti-E-Cadherin/Cadherin-1 Antibody (8U274) 是一种 Rabbit 抗体，靶向 E-Cadherin/Cadherin-1。Anti-E-Cadherin/Cadherin-1 Antibody (8U274) 可用于 IHC-P,ICC/IF。
Anti-E-Cadherin/Cadherin-1 Antibody (8U274)
Anti-E-Cadherin/Cadherin-1 Antibody (8U274)
还可以产品编号 TMAY-00462
Anti-E-Cadherin/Cadherin-1 Antibody (8U274) 是一种 Rabbit 抗体，靶向 E-Cadherin/Cadherin-1。Anti-E-Cadherin/Cadherin-1 Antibody (8U274) 可用于 IHC-P,ICC/IF。
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偶联与修饰
抗原信息
| 产品描述 | Anti-E-Cadherin/Cadherin-1 Antibody (8U274) is a Rabbit antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (8U274) can be used in IHC-P,ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8U274 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human E-cadherin in human skin with rabbit monoclonal Antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells. 2. Immunochemical staining of human E-cadherin in human gastric cancer with rabbit monoclonal Antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells. 3. Immunofluorescence staining of CD324 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-human CD324 monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). |
| 应用 | IHC-P,ICC/IF |
| 推荐剂量 | IHC-P: 1:100-1:500; ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad (rh E-cadherin / CDH1 / Cadherin-1 / E-Cad; NP_004351.1Met1-Ile707). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad protein |
| 抗原种属 | Human |
| 研究领域 | Hemangioblast Markers, Tumor Suppressors |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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