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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RAF1 (Ser259) Antibody (2M259)

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Anti-Phospho-RAF1 (Ser259) Antibody (2M259)
产品编号 TMAC-03257
别名 RAF1 (p-Ser259), RAF1 (p-S259), p-RAF1 (Ser259), p-RAF1 (S259), Phospho-RAF1 (S259)

Anti-Phospho-RAF1 (S259) Antibody (2M259) 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (S259)。Anti-Phospho-RAF1 (S259) Antibody (2M259) 可用于 WB,IHC。

Anti-Phospho-RAF1 (Ser259) Antibody (2M259)

Anti-Phospho-RAF1 (Ser259) Antibody (2M259)

Rating icon 还可以
Anti-Phospho-RAF1 (Ser259) Antibody (2M259)
产品编号 TMAC-03257 别名 RAF1 (p-Ser259), RAF1 (p-S259), p-RAF1 (Ser259), p-RAF1 (S259), Phospho-RAF1 (S259)

Anti-Phospho-RAF1 (S259) Antibody (2M259) 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (S259)。Anti-Phospho-RAF1 (S259) Antibody (2M259) 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RAF1 (Ser259) Antibody (2M259) 是一种 Rabbit 抗体，靶向 Phospho-RAF1 (Ser259)。Anti-Phospho-RAF1 (Ser259) Antibody (2M259) 可用于 WB,IHC。
别名RAF1 (p-Ser259), RAF1 (p-S259), p-RAF1 (Ser259), p-RAF1 (S259), Phospho-RAF1 (S259)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Phospho-Raf1 (S259) on different lysates using anti-Phospho-Raf1 (S259) antibody at 1/1,000 dilution. Positive control: Lane 1: Human skeletal muscle, Lane 2: Hela.
2. Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-Phospho-Raf1 (S259) antibody. Counter stained with hematoxylin.
应用
WB
IHC
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Raf-1 is a ubiquitously expressed cytoplasmic protein with intrinsic serine/threonine kinase activity. Raf-1, or c-Raf, is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein is associated with cellular transformation and mitogenesis. Raf-1 is normally suppressed by its regulatory N-terminal domain. Raf-1 is activated in response to a variety of tyrosine kinase receptors as well as in response to pp60v-Src expression. Specifically, Raf-1 is phosphorylated in the catalytic domain at Ser 338 and, to a lesser extent, Ser 339. This phosphorylation requires the co-activation of PI 3-kinase and the Ras signaling pathway. Raf-1 is also phosphorylated on Tyr 340 and 341, which induces the phosphorylation of MEK. Phosphorylation of Ser 621 is essential for the catalytic activity of Raf-1 and downregulation by c-AMP-dependent protein kinase A (PKA). PKA also phosphorylates Raf-1 on Ser 43 and Ser 259. PKA phosphorylation of Ser 259 inhibits Raf-1 and decreases the phosphorylation necessary for Raf-1 activation at Ser 338.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human Raf1 around the phosphorylation site of Ser259
抗原种属
human
Uniprot ID
P04049
化学信息
分子量Theoretical: 73 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

RAF1 (pSer259)RAF1 (pS259)RAF1 (phospho-Ser259)RAF1 (phospho-S259)Raf-1RAF1RAF proto-oncogene serine/threonine-protein kinaseRAF 1RAFProto-oncogene c-RAF (cRaf)pRAF1 (Ser259)pRAF1 (S259)c-RafcRaf

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4个月前
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