Name: Anti-CDH1/E-cadherin/CD324 Antibody
Brand: TargetMol
SKU: T9901A-1434
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-CDH1/E-cadherin/CD324 Antibody is a monoclonal antibody targeting E-cadherin (encoded by the CDH1 gene). E-cadherin is a calcium-dependent cell adhesion molecule essential for maintaining the structural integrity and polarity of epithelial cells. By specifically binding to the extracellular domain of E-cadherin, this antibody is frequently utilized to study cell-cell adhesion mechanisms, the epithelial-mesenchymal transition (EMT) process, and tumor invasion and metastasis. In various cancers, the downregulation or loss of E-cadherin is considered a key hallmark of malignant progression and metastasis.
体外活性	在免疫荧光研究中，Anti-CDH1/E-cadherin/CD324 Antibody表现出与上皮组织（如肠粘膜和肾小管）强效且特异的反应性，主要定位于质膜的细胞间接触面 [1]。
体内活性	在小鼠胚胎实验中，将Anti-CDH1/E-cadherin/CD324 Antibody（抗 uvomorulin）加入 8 细胞期胚胎后，在 2-4 小时内引起了完全的解紧密现象，证明该抗体能有效破坏囊胚形成所需的钙依赖性细胞粘附 [1]。
别名	抗CDH1/E-cadherin/CD324抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P12830
靶点	CDH1/E-cadherin/CD324

储存&溶解度

存储

Anti-CDH1/E-cadherin/CD324 Antibody