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GRO beta/CXCL2 Protein, Human, Recombinant

GRO beta/CXCL2 Protein, Human, Recombinant

产品编号 TMPY-00006
别名: GROb, MIP-2a, CINC-2a, GRO β/CXCL2, MIP2, MGSA-b, GRO2, MIP2A, SCYB2, chemokine (C-X-C motif) ligand 2

GRO beta/CXCL2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is A0A024RDD9.

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GRO beta/CXCL2 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
10 μg ¥ 1,050 现货
100 μg ¥ 3,930 5日内发货
1 mg ¥ 25,600 5日内发货
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产品目录号及名称: GRO beta/CXCL2 Protein, Human, Recombinant (TMPY-00006)
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生物活性 Testing in progress
产品描述 GRO beta/CXCL2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is A0A024RDD9.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 A0A024RDD9
别名 GROb, MIP-2a, CINC-2a, GRO β/CXCL2, MIP2, MGSA-b, GRO2, MIP2A, SCYB2, chemokine (C-X-C motif) ligand 2
蛋白构建 Human CXCL2 (NP_002080.1) (Ala35-Asn107)
蛋白纯度 > 95 % as determined by SDS-PAGE.
分子量 7.9 kDa (predicted)
内毒素 Please contact us for more information.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 1 M NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.

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Keywords

GRO beta/CXCL2 Protein, Human, Recombinant GROb SCYB-2 GRO 2 MIP-2a CINC-2a GRO β/CXCL2 GRO-2 MIP2 MGSA-b GRO2 MIP2A SCYB2 MIP-2 chemokine (C-X-C motif) ligand 2 SCYB 2 MIP 2 recombinant recombinant-proteins proteins protein

 

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