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IGF1 LR3 Protein, Human, Recombinant

产品编号 TMPY-04942

别名: IGF‑I, insulin-like growth factor 1 (somatomedin C), IGF-1, IGF1A, 胰岛素样生长因子, IGFI, MGF, IGF-I

IGF1 LR3 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 9.1 kDa and the accession number is P05019-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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IGF1 LR3 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
200 μg	￥ 730		5日内发货
1 mg	￥ 1,760		5日内发货

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参考文献

生物活性	Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically 1.5-6 ng/mL.
产品描述	IGF1 LR3 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 9.1 kDa and the accession number is P05019-1.

种属	Human
表达系统	P. pastoris (Yeast)
标签	Tag Free
蛋白编号	P05019-1
别名	IGF‑I, insulin-like growth factor 1 (somatomedin C), IGF-1, IGF1A, 胰岛素样生长因子, IGFI, MGF, IGF-I
蛋白构建	The Human IGF1 (P05019-1) (Gly49-Ala118, with mutation Glu 51 Arg) was expressed with a 13 amino acids (MFPAMPLSSLFVN) at its N-terminus.
蛋白纯度	> 95% as determined by SDS-PAGE.
分子量	9.1 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.

参考文献

1. Jansen M., et al.,(1983), Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609-611. 2. de Pagter-Holthuizen P., et al., (1986), Organization of the human genes for insulin-like growth factors I and II.FEBS Lett. 195:179-184. 3. le Bouc Y., et al.,(1986), Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.FEBS Lett. 196:108-112.

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Keywords

IGF1 LR3 Protein, Human, Recombinant IGF‑I insulin-like growth factor 1 (somatomedin C) IGF-1 IGF1A somatomedin C 胰岛素样生长因子 IGFI IGF1 MGF IGF-I IGF 1 insulin-like growth factor 1 recombinant recombinant-proteins proteins protein

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