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Anti-TRK fused gene Antibody (4L658)

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产品编号 TMAC-04130

别名 TRKT3 oncogene, TRKT3, TRK-fused gene protein, TRK fused gene protein, TRK fused gene, TRK fused, TFG_HUMAN, TFG, TF6, SPG57, Protein TFG, OTTHUMP00000214048, OTTHUMP00000214047, OTTHUMP00000214046, OTTHUMP00000214045, HMSNP, FLJ36137

Anti-TRK fused gene Antibody (4L658) 是一种 Rabbit 抗体，靶向 TRK fused gene。Anti-TRK fused gene Antibody (4L658) 可用于 ICC/IF,IHC,IP,WB。

Anti-TRK fused gene Antibody (4L658)

Anti-TRK fused gene Antibody (4L658)

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Rating icon 还可以
产品编号 TMAC-04130 别名 TRKT3 oncogene, TRKT3, TRK-fused gene protein, TRK fused gene protein, TRK fused gene, TRK fused, TFG_HUMAN, TFG, TF6, SPG57, Protein TFG, OTTHUMP00000214048, OTTHUMP00000214047, OTTHUMP00000214046, OTTHUMP00000214045, HMSNP, FLJ36137

Anti-TRK fused gene Antibody (4L658) 是一种 Rabbit 抗体，靶向 TRK fused gene。Anti-TRK fused gene Antibody (4L658) 可用于 ICC/IF,IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-TRK fused gene Antibody (4L658) is a Rabbit antibody targeting TRK fused gene. Anti-TRK fused gene Antibody (4L658) can be used in ICC/IF,IHC,IP,WB.
别名TRKT3 oncogene, TRKT3, TRK-fused gene protein, TRK fused gene protein, TRK fused gene, TRK fused, TFG_HUMAN, TFG, TF6, SPG57, Protein TFG, OTTHUMP00000214048, OTTHUMP00000214047, OTTHUMP00000214046, OTTHUMP00000214045, HMSNP, FLJ36137
Ig Type
IgG
克隆号
4L658
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of TRK fused gene on different lysates using anti-TRK fused gene antibody at 1/5,000 dilution. Positive control: Lane 1: 293T, Lane 2: Hela.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin.
6. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TRK fused gene antibody. Counter stained with hematoxylin.
7. ICC staining TRK fused gene in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining TRK fused gene in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
9. ICC staining TRK fused gene in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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应用ICC/IFIHCIPWB
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, are frequently detected in thyroid carcinomas. Such rearrangements fuse the NTRK1 tyrosine kinase domain to 5'-end sequences of different genes. TRK-T3 contains 1,412 nucleotides of NTRK1 preceded by 598 nucleotides belonging to TFG (TRK-fused gene), a ubiquitously expressed gene located on chromosome 3. The TRK-T3 protein within the TFG region contains a coiled-coil motif that gives the oncoprotein the capability to form complexes. The cytoplasmic TRK-T3 protein binds to and phosphorylates the Shc and SNT1/FRS2 adaptor proteins, both of which are involved in coupling the receptor tyrosine kinase to the mitogen-activated protein kinase pathway by recruiting Grb2/SOS. SHP-1 also interacts with and down-regulates TRK-T3.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q92734
化学信息
分子量Theoretical: 55 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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